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Titolo:
Interpretation of sequential measurements of cancer antigen 125 (CA 125), carcinoembryonic antigen (CEA), and tissue polypeptide antigen (TPA) based on analytical imprecision and biological variation in the monitoring of ovarian cancer
Autore:
Tuxen, MK; Soletormos, G; Petersen, PH; Dombernowsky, P;
Indirizzi:
Univ Copenhagen, Herlev Hosp, Dept Oncol, Copenhagen, Denmark Univ Copenhagen Copenhagen Denmark osp, Dept Oncol, Copenhagen, Denmark Univ Copenhagen, Herlev Hosp, Dept Clin Chem, Copenhagen, Denmark Univ Copenhagen Copenhagen Denmark Dept Clin Chem, Copenhagen, Denmark Hvidovre Univ Hosp, Dept Internal Med, Copenhagen, Denmark Hvidovre Univ Hosp Copenhagen Denmark Internal Med, Copenhagen, Denmark Cent Hosp Hillerod, Dept Clin Biochem, DK-3400 Hillerod, Denmark Cent HospHillerod Hillerod Denmark DK-3400 m, DK-3400 Hillerod, Denmark Odense Univ Hosp, Dept Clin Biochem, DK-5000 Odense, Denmark Odense Univ Hosp Odense Denmark DK-5000 Biochem, DK-5000 Odense, Denmark
Titolo Testata:
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
fascicolo: 6, volume: 39, anno: 2001,
pagine: 531 - 538
SICI:
1434-6621(200106)39:6<531:IOSMOC>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
SERUM TUMOR-MARKERS; CLINICAL-CHEMISTRY; ANALYTICAL GOALS; BREAST-CANCER; FOLLOW-UP; CARCINOMA; CA-125; CHEMOTHERAPY;
Keywords:
CA 125; CEA; TPA; statistics; biological variation; analytical variation; reference change value; signal-to-noise ratio; logarithmic transformation; probit transformation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Soletormos, G Cent Hosp Hillerod, Dept Clin Biochem, Helsevej 2, DK-3400 Hillerod, Denmark Cent Hosp Hillerod Helsevej 2 Hillerod Denmark DK-3400 mark
Citazione:
M.K. Tuxen et al., "Interpretation of sequential measurements of cancer antigen 125 (CA 125), carcinoembryonic antigen (CEA), and tissue polypeptide antigen (TPA) based on analytical imprecision and biological variation in the monitoring of ovarian cancer", CLIN CH L M, 39(6), 2001, pp. 531-538

Abstract

The main objective with cancer antigen 125 (CA 125), carcinoembryonic antigen (CEA), and tissue polypeptide antigen (TPA) monitoring of ovarian cancer patients is to detect an early change of disease activity with high reliability. We hypothesized that a monitoring scheme for ovarian cancer patients with serological tumor markers should take into account the stochastic variation, Le. the probability that observed increases and decreases may solely be due to analytical imprecision and normal intra-individual biological variation. The aim of this study was to provide a detailed characteristic of the within-subject mean steady state concentrations and the associated variability in healthy individuals with an age distribution representative for ovarian cancer patients. Thirty-one healthy women with a median age of 55years comprised the study population. Sixteen blood samples were collectedfrom each subject in four series, with four samples per series, over a period of approximately 1 year. We found that, i) natural logarithmic-transformed concentrations were more homogeneously distributed between individuals than the original concentrations, ii) the within-subject mean steady state levels, the standard deviations, and the coefficients of variation differedamong subjects, and iii) the steady state variability differed among the markers. In conclusion, our data indicate that the assessment of sequential CA 125, CEA, and TPA concentrations is more complex than hitherto recognized. We suggest that it is necessary to adjust the assessment criteria to thetype of marker, and that assessment may be facilitated if based on naturallogarithmic transformed concentrations.

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Documento generato il 07/04/20 alle ore 22:43:35