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Titolo:
Plasma endothelin-1 and big endothelin-1 levels in superior and inferior vena cava during protracted antiorthostatic hypokinetic/hypodynamia in rats
Autore:
Capodicasa, E; Tassi, C; Rossi, R; Biondi, R;
Indirizzi:
Univ Perugia, Dipartimento Med Clin & Sperimentale, Monteluce Policlin, I-06100 Perugia, Italy Univ Perugia Perugia Italy I-06100 luce Policlin, I-06100 Perugia, Italy Univ Perugia, Dipartimento Sci Biochim & Biotecnol Mol, I-06100 Perugia, Italy Univ Perugia Perugia Italy I-06100 Biotecnol Mol, I-06100 Perugia, Italy
Titolo Testata:
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
fascicolo: 6, volume: 39, anno: 2001,
pagine: 509 - 513
SICI:
1434-6621(200106)39:6<509:PEABEL>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONVERTING ENZYME; CELLS; PATHOPHYSIOLOGY; LOCALIZATION; PHARMACOLOGY; BRAIN;
Keywords:
big endothelin-1; endothelin-1; endothelin-converting enzyme; antiorthostatic hypokinetic/hypodynamia; head-down suspension; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Capodicasa, E Univ Perugia, Dipartimento Med Clin & Sperimentale, Monteluce Policlin, I-06100 Perugia, Italy Univ Perugia Perugia Italy I-06100 I-06100 Perugia, Italy
Citazione:
E. Capodicasa et al., "Plasma endothelin-1 and big endothelin-1 levels in superior and inferior vena cava during protracted antiorthostatic hypokinetic/hypodynamia in rats", CLIN CH L M, 39(6), 2001, pp. 509-513

Abstract

The plasma levels of endothelin-1 and big endothelin-1 were evaluated in blood of rats in the superior and inferior vena cava, in normal posture (synchronous controls), and after 12 days head-down suspension and 1 day recovery in normal posture. In synchronous controls, the mean plasma concentration of endothelin-1 in inferior vena cava or superior vena cava was almost the same (5.89 +/- 0.63 pmol/l and 5.67 +/- 0.64 pmol/l, respectively), whereas the mean plasma concentration of big endothelin-1 was higher (p <0.05) in superior vena cava compared to inferior vena cava (5.49 +/-0.75 pmol/l and 1.39 +/-0.15 pmol/l, respectively). In samples from superior vena cava ofhead-down suspended rats big endothelin-1 levels were significantly lower (p <0.05) up to day 9 of suspension, compared to non-suspended synchronous controls, whereas endothelin-1 values were higher (p <0.05). Big endothelin-1 concentration was higher (p <0.05) in inferior vena cava compared to non-suspended synchronous controls. The behaviour of endothelin-1 was more complex, endothelin-1 levels were lower (p <0.05) on day 1 of head-down suspension and higher (p <0.05) in samples taken on days 9 and 12. After 1 day recovery endothelin-1 and big endothelin-1 concentrations returned to normal in both superior vena cava and inferior vena cava. These data indicate thatthe endothelial system involvement for the two venous beds is different and suggest that local rather than systemic evaluation could better explain endothelial involvement and the contribution of different anatomic sites to the biosynthesis, conversion and clearance of the various involved molecules.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 17:45:25