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Titolo:
Mediastinal lymph node sampling following positron emission tomography with fluorodeoxyglucose imaging in lung cancer staging
Autore:
Gupta, NC; Tamim, WJ; Graeber, GG; Bishop, HA; Hobbs, GR;
Indirizzi:
W Virginia Univ, PET Ctr, Robert C Byrd Hlth Sci Ctr S, Morgantown, WV 26506 USA W Virginia Univ Morgantown WV USA 26506 i Ctr S, Morgantown, WV 26506 USA Robert C Byrd Hlth Sci Ctr, Dept Surg, Morgantown, WV USA Robert C Byrd Hlth Sci Ctr Morgantown WV USA pt Surg, Morgantown, WV USA
Titolo Testata:
CHEST
fascicolo: 2, volume: 120, anno: 2001,
pagine: 521 - 527
SICI:
0012-3692(200108)120:2<521:MLNSFP>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
SOLITARY PULMONARY NODULES; BRONCHOGENIC-CARCINOMA; PET; CT; EFFICACY;
Keywords:
fluorodeoxyglucose; lung cancer; lymph node staging; positron emission tomography;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Gupta, NC W Virginia Univ, PET Ctr, Robert C Byrd Hlth Sci Ctr S, Morgantown, WV 26506 USA W Virginia Univ Morgantown WV USA 26506 organtown, WV 26506 USA
Citazione:
N.C. Gupta et al., "Mediastinal lymph node sampling following positron emission tomography with fluorodeoxyglucose imaging in lung cancer staging", CHEST, 120(2), 2001, pp. 521-527

Abstract

Objectives: To evaluate, the predictive accuracy as well as the rates of false-positive and false-negative results of CT and positron emission tomography (PET)-fluorodeoxyglucose (FDG) imaging in detecting the metastatic intrathoracic lymph nodes in patients with suspected or proven non-small cell lung cancer (NSCLC). Our other objective was to determine the need for routine invasive sampling procedure in confirming PET/CT staging results. Methods: The results of CT and PET-FDG scanning in 77 patients with suspected or proven NSCLC were correlated with the histologic findings of hilar/mediastinal lymph node sampling using mediastinoscopy, open biopsy, thoracotomy, or thoracotomy with resection. Patients were then classified into resectable and unresectable groups based initially on PET results and compared to histologic findings. Results: The sensitivity, specificity, and accuracy of CT and PET for detecting metastatic lymphadenopathy were 68%, 61%, 63%, and 87%, 91%, and 82%,respectively. A change of management with routine sampling following PET was seen in five of six patients (83%) with false-positive findings (13%) but in none of four patients (9%) with false-negative findings. Conclusion: The false-positive findings of PET-FDG imaging affected selection of treatment in 83% of patients. However, false-negative results did not change management in any patient. This could potentially prevent unnecessary invasive thoracotomy, mediastinoscopy, or other sampling procedures in patients with negative PET results.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/08/20 alle ore 05:01:10