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Titolo:
A polymorphic genomic duplication on human chromosome 15 is a susceptibility factor for panic and phobic disorders
Autore:
Gratacos, M; Nadal, M; Martin-Santos, R; Pujana, MA; Gago, J; Peral, B; Armengol, L; Ponsa, I; Miro, R; Bulbena, A; Estivill, X;
Indirizzi:
IRO, Ctr Genet Med & Mol, E-08907 Barcelona, Catalonia, Spain IRO Barcelona Catalonia Spain E-08907 E-08907 Barcelona, Catalonia, Spain Hosp Mare Deu Esperanca, IMAS, Dept Psiquiatria, E-08083 Barcelona, Catalonia, Spain Hosp Mare Deu Esperanca Barcelona Catalonia Spain E-08083 atalonia, Spain IMIM, Unitat Recerca Psiquiatria, E-08083 Barcelona, Catalonia, Spain IMIM Barcelona Catalonia Spain E-08083 -08083 Barcelona, Catalonia, Spain Univ Autonoma Barcelona, Dept Biol Cellular Fisiol & Immunol, E-08193 Bellaterra, Catalonia, Spain Univ Autonoma Barcelona Bellaterra Catalonia Spain E-08193 talonia, Spain
Titolo Testata:
CELL
fascicolo: 3, volume: 106, anno: 2001,
pagine: 367 - 379
SICI:
0092-8674(20010810)106:3<367:APGDOH>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
JOINT HYPERMOBILITY SYNDROME; ANXIETY DISORDERS; TRK FAMILY; NEUROTROPHIN-3; ASSOCIATION; DEPRESSION; HYPOTHESIS; PLASTICITY; RECEPTOR; SYSTEM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Estivill, X IRO, Ctr Genet Med & Mol, E-08907 Barcelona, Catalonia, Spain IRO Barcelona Catalonia Spain E-08907 elona, Catalonia, Spain
Citazione:
M. Gratacos et al., "A polymorphic genomic duplication on human chromosome 15 is a susceptibility factor for panic and phobic disorders", CELL, 106(3), 2001, pp. 367-379

Abstract

Anxiety disorders are complex and common psychiatric illnesses associated with considerable morbidity and social cost. We have studied the molecular basis of the cooccurrence of panic and phobic disorders with joint laxity. We have identified an interstitial duplication of human chromosome 15q24-26(named DUP25), which is significantly associated with panic/agoraphobia/social phobia/joint laxity in families, and with panic disorder in nonfamilial cases. Mosaicism, different forms of DUP25 within the same family, and absence of segregation of 15q24-26 markers with DUP25 and the psychiatric phenotypes suggest a non-Mendelian mechanism of disease-causing mutation. We propose that DUP25, which is present in 7% control subjects, is a susceptibility factor for a clinical phenotype that includes panic and phobic disorders and joint laxity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 02:23:47