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Titolo:
Angiogenesis gene therapy to rescue ischaemic tissues: achievements and future directions
Autore:
Emanueli, C; Madeddu, P;
Indirizzi:
Natl Inst Biostruct & Biosyst, Natl Lab, Cardiovasc Med & Gene Therapy Sect, Osilo, Italy Natl Inst Biostruct & Biosyst Osilo Italy ne Therapy Sect, Osilo, Italy Med Univ Sassari, Dept Internal Med, Sassari, Italy Med Univ Sassari Sassari Italy ssari, Dept Internal Med, Sassari, Italy
Titolo Testata:
BRITISH JOURNAL OF PHARMACOLOGY
fascicolo: 7, volume: 133, anno: 2001,
pagine: 951 - 958
SICI:
0007-1188(200108)133:7<951:AGTTRI>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIAL GROWTH-FACTOR; NORMOPERFUSED SKELETAL-MUSCLE; COLLATERAL VESSEL DEVELOPMENT; CORONARY-ARTERY DISEASE; ISCHEMIC-HEART-DISEASE; IN-VIVO; LIMB ISCHEMIA; PHASE-I; MYOCARDIAL ANGIOGENESIS; STIMULATES ANGIOGENESIS;
Keywords:
angiogenesis; endothelium; gene therapy; growth factors; ischaemia; viral vectors;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
69
Recensione:
Indirizzi per estratti:
Indirizzo: Madeddu, P Natl Inst Biostruct & Biosyst, Natl Lab, Gene Therapy Sect, Viale S Antonio, I-07033 Osilo, Italy Natl Inst Biostruct & Biosyst Viale S Antonio Osilo Italy I-07033
Citazione:
C. Emanueli e P. Madeddu, "Angiogenesis gene therapy to rescue ischaemic tissues: achievements and future directions", BR J PHARM, 133(7), 2001, pp. 951-958

Abstract

Ischaemic diseases are characterized by an impaired supply of blood resulting from narrowed or blocked arteries that starve tissues of needed nutrients and oxygen. Coronary-atherosclerosis induced myocardial infarction is one of the leading causes of mortality in developed countries. Ischaemic disease also affects the lower extremities. Considerable advances in both surgical bypassing and percutaneous revascularization techniques have been reached. However, many patients cannot benefit from these therapies because of the extension of arterial occlusion and/or microcirculation impairment. Consequently, the need for alternative therapeutic strategies is compelling. Aninnovative approach consists of stimulating collateral vessel growth, a natural host defence response that intervenes upon occurrence of critical reduction in tissue perfusion (Isner & Asahara, 1999). This review will debatethe relevance of therapeutic angiogenesis for promotion of tissue repair. The following issues will receive attention: (a) vascular growth patterns, (b) delivery systems for angiogenesis gene transfer, (c) achievements of therapeutic angiogenesis in myocardial and peripheral ischaemia, and (d) future directions to improve effectiveness and safety of vascular gene therapy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 07:28:12