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Titolo:
Use of selective serotonin reuptake inhibitors and risk of developing first-time acute myocardial infarction
Autore:
Meier, CR; Schlienger, RG; Jick, H;
Indirizzi:
Univ Basel Hosp, Basel Pharmacoepidemiol Unit, Div Clin Pharmacol, CH-4031Basel, Switzerland Univ Basel Hosp Basel Switzerland CH-4031 col, CH-4031Basel, Switzerland Boston Univ, Med Ctr, Boston Collaborat Drug Surveillance Program, Lexington, MA USA Boston Univ Lexington MA USA rug Surveillance Program, Lexington, MA USA Univ Basel, Inst Clin Pharm, Dept Pharm, Basel, Switzerland Univ Basel Basel Switzerland Clin Pharm, Dept Pharm, Basel, Switzerland
Titolo Testata:
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
fascicolo: 2, volume: 52, anno: 2001,
pagine: 179 - 184
SICI:
0306-5251(200108)52:2<179:UOSSRI>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRACTICE RESEARCH DATABASE; HEART-DISEASE; ANTIDEPRESSANT DRUGS; PLATELET SEROTONIN; FOLLOW-UP; DEPRESSION; FLUOXETINE; PAROXETINE; MORTALITY; HYPERTENSION;
Keywords:
antidepressive agents; case-control study; epidemiology; myocardial infarction; serotonin uptake inhibitors; serotonin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Meier, CR Univ Basel Hosp, Basel Pharmacoepidemiol Unit, Div Clin Pharmacol, Petersgraben 4, CH-4031 Basel, Switzerland Univ Basel Hosp Petersgraben 4 Basel Switzerland CH-4031 erland
Citazione:
C.R. Meier et al., "Use of selective serotonin reuptake inhibitors and risk of developing first-time acute myocardial infarction", BR J CL PH, 52(2), 2001, pp. 179-184

Abstract

Aims Selective serotonin reuptake inhibitors (SSRIs) have been associated with serotonin depletion in platelets, potentially leading to abnormal aggregation and prolonged bleeding time. In view of the importance of serotoninin coronary thrombosis, and decreased platelet serotonin concentrations associated with SSRIs, the present study was performed to test the hypothesisof a decreased risk of acute myocardial infarction (AMI) associated with SSRIs. Methods We conducted a population-based case-control analysis using the UKGeneral Practice Research Database (GPRD). A total of 3319 patients aged 75 years or younger free of clinical conditions predisposing to ischaemic heart disease, with a first-time diagnosis of AMI between 1992 and 1997, and 13 139 controls without AMI matched to cases for age, sex, general practiceattended, and calendar time were included. Conditional logistic regressionwas used to estimate relative risks. Results Adjusted odds ratios (with 95% CI) for current use of SSRIs, non-SSRIs, or other antidepressants, compared to the group of nonusers of antidepressants were 0.9 (95% CI 0.5,1.8), 0.9 (95% CI 0.7,1.2), and 1.3 (95% CI 0.6,2.8), respectively. As compared with nonuse of SSRIs, current use (regardless of any other antidepressants used) resulted in an adjusted OR of 1.1(95% CI 0.7,1.6). Conclusions The current analysis provides evidence that SSRI exposure doesnot substantially decrease the risk of developing first-time AMI in patients free of factors predisposing to ischaemic heart disease. However, due torelatively small numbers of exposed subjects and the resulting wide confidence intervals, further studies may be needed to document a lack of effect of SSRIs in subjects without pre-existing diseases predisposing to AMI.

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Documento generato il 03/04/20 alle ore 20:40:13