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Titolo:
Effects of L-arginine on the kidney levels of malondialdehyde in rats submitted to renal ischaemia-reperfusion
Autore:
Rhoden, EL; Lucas, ML; Pereira-Lima, L; Rhoden, CR; Souto, CAV;
Indirizzi:
Fac Ciencias Med Porto Alegre, Fdn Fac, Dept Gen Surg, Santa Casa Porto Alegre, RS, Brazil Fac Ciencias Med Porto Alegre Santa Casa Porto Alegre RS Brazil , Brazil Fac Ciencias Med Porto Alegre, Fdn Fac, Dept Pharmacol & Urol, Santa Casa Porto Alegre, RS, Brazil Fac Ciencias Med Porto Alegre Santa Casa Porto Alegre RS Brazil , Brazil
Titolo Testata:
BJU INTERNATIONAL
fascicolo: 3, volume: 88, anno: 2001,
pagine: 273 - 277
SICI:
1464-4096(200108)88:3<273:EOLOTK>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE METABOLISM; LIPID-PEROXIDATION; ISCHEMIA; INJURY; MECHANISMS; FAILURE; ISCHEMIA/REPERFUSION; INHIBITION; DAMAGE;
Keywords:
nitric oxide; kidney; ischaemia; L-arginine; malondialdehyde;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Rhoden, EL Rua Jaragua 370-302,Bairro Bela Vista, BR-90450140 Porto Alegre, RS, Brazil Rua Jaragua 370-302,Bairro Bela Vista Porto Alegre RS Brazil BR-90450140 BC
Citazione:
E.L. Rhoden et al., "Effects of L-arginine on the kidney levels of malondialdehyde in rats submitted to renal ischaemia-reperfusion", BJU INT, 88(3), 2001, pp. 273-277

Abstract

Objective To evaluate the effects of L-arginine, a nitric oxide donor, on kidney levels of malondialdehyde (MDA, a product of cellular lipid peroxidation), serum creatinine levels, and urinary volume in rats undergoing unilateral renal ischaemia-reperfusion. Materials and methods Wistar rats (117) were randomly distributed into three experimental groups (of four subgroups each) in which were assessed renal cell-lipid peroxidation (kidney levels of MDA), serum creatinine levels and urinary volume. The rats underwent unilateral nephrectomy followed by contralateral renal ischaemia-reperfusion with or with no pretreatment with L-arginine (200 mg/kg) given intraperitoneally. Results Pretreatment with L-arginine caused significantly higher kidney levels of MDA than in the untreated group (P<0.05). Furthermore, L-arginine given before surgery attenuated the increase in serum creatinine and significantly increased urinary volume in rats subjected to renal ischaemia-reperfusion (P < 0.05). Conclusion L-arginine tended to be of benefit for renal function during renal ischaemia-reperfusion in rats. Pretreatment with L-arginine (200 mg/kg intraperitoneally) seems to increase the renal damage by increasing kidney levels of MDA.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/02/20 alle ore 08:07:53