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Titolo:
An autoradiographic study of regional blood flow distribution in the rat kidney during ureteric obstruction - the role of vasoactive compounds
Autore:
Sweeney, P; Young, LS; Fitzpatrick, JM;
Indirizzi:
Mater Misericordiae Hosp, Dept Urol Surg, Dublin 7, Ireland Mater Misericordiae Hosp Dublin Ireland 7 t Urol Surg, Dublin 7, Ireland Univ Coll Dublin, Dublin 2, Ireland Univ Coll Dublin Dublin Ireland 2Univ Coll Dublin, Dublin 2, Ireland
Titolo Testata:
BJU INTERNATIONAL
fascicolo: 3, volume: 88, anno: 2001,
pagine: 268 - 272
SICI:
1464-4096(200108)88:3<268:AASORB>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRESSURE; DOG;
Keywords:
ureteric obstruction; autoradiography; renal blood flow;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Fitzpatrick, JM 47 Eccles St, Dublin 7, Ireland 47 Eccles St Dublin Ireland 7 cles St, Dublin 7, Ireland
Citazione:
P. Sweeney et al., "An autoradiographic study of regional blood flow distribution in the rat kidney during ureteric obstruction - the role of vasoactive compounds", BJU INT, 88(3), 2001, pp. 268-272

Abstract

Objective To determine the changes in regional renal blood flow during ureteric obstruction and to examine the role of vasoactive mediators in effecting these changes. Materials and methods Renal blood flow in Sprague-Dawley rats was assessedafter periods of ureteric obstruction using a quantitative autoradiographic technique based on Kety's theory of diffusion of an inert tracer (C-14-iodoantipyrine). Prostaglandins, thromboxanes and renin-angiotensin were inhibited pharmacologically using diclofenac sodium and enalapril. Results Baseline blood flow to the outer cortex, inner cortex and medulla was 807,258 and 105 mL/100 g/min, respectively. There was an increase in outer cortical blood flow after 10 min of ureteric obstruction which became significant at 30 min (P < 0.05). There was a significant decrease in inner cortical and medullary blood flow at 30 min, to 210 and 68 mL/100 g/min, respectively (P < 0.05). Diclofenac sodium abolished the increase fit outer cortical blood flow. After 24 h or unilateral ureteric obstruction, outer cortical blood How decreased to 492 mL/100 g/min; inner cortical blood flow also decreased but to a lesser extent, to 190 mL/100 g/min. Inhibition of prostaglandins, thromboxanes and the renin-angiotensin system reduced the degree of renal vasoconstriction but there was still a significant decrease inouter cortical perfusion despite the presence of these blocking agents. Conclusions The control of the renal vasculature involves a complex interplay between a variety of vasoactive mediators. Quantitative autoradiographyoffers the Opportunity to evaluate changes in regional renal perfusion with high resolution and will allow it greater understanding of the pathophysiology of renal diseases.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 00:39:00