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Titolo:
Treatment with sildenafil citrate in renal transplant patients with erectile dysfunction
Autore:
Castro, RMP; Curado, FJA; Lopez, JCR; Vallejo, MEL; Sanchez, JM; Lopez, JLS; Tapia, MJR;
Indirizzi:
Univ Cordoba, Fac Med, Cordoba, Spain Univ Cordoba Cordoba SpainUniv Cordoba, Fac Med, Cordoba, Spain Reg Univ Hosp Reina Sofia, Dept Surg, Androl Transplantat Unit, Cordoba, Spain Reg Univ Hosp Reina Sofia Cordoba Spain ansplantat Unit, Cordoba, Spain Reg Univ Hosp Reina Sofia, Dept Urol, Androl Transplantat Unit, Cordoba, Spain Reg Univ Hosp Reina Sofia Cordoba Spain ansplantat Unit, Cordoba, Spain Reg Univ Hosp Reina Sofia, Dept Urol, Renal Transplantat Unit, Cordoba, Spain Reg Univ Hosp Reina Sofia Cordoba Spain ansplantat Unit, Cordoba, Spain Reg Univ Hosp Reina Sofia, Dept Surg, Renal Transplantat Unit, Cordoba, Spain Reg Univ Hosp Reina Sofia Cordoba Spain ansplantat Unit, Cordoba, Spain
Titolo Testata:
BJU INTERNATIONAL
fascicolo: 3, volume: 88, anno: 2001,
pagine: 241 - 243
SICI:
1464-4096(200108)88:3<241:TWSCIR>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
ORAL SILDENAFIL; DOUBLE-BLIND; IMPOTENCE; FAILURE; SAFETY;
Keywords:
sildenafil; renal; transplant; impotence; safety; efficacy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
13
Recensione:
Indirizzi per estratti:
Indirizzo: Castro, RMP Calle Algarrobo 7-3-1, Cordoba 14006, Spain Calle Algarrobo 7-3-1 Cordoba Spain 14006 rdoba 14006, Spain
Citazione:
R.M.P. Castro et al., "Treatment with sildenafil citrate in renal transplant patients with erectile dysfunction", BJU INT, 88(3), 2001, pp. 241-243

Abstract

Objective To assess the safety and efficacy of sildenafil citrate in renaltransplant patients with erectile dysfunction, as up to half of men with renal failure may be affected and only 60-75% recover potency after transplantation. Patients and methods Fifty patients with erectile dysfunction and a functioning renal transplant were treated using sildenafil (mean age 54 years, mean time on dialysis 35 months, mean time from transplantation 20 months). The hypogastric artery was not used during transplantation in any patient. Sildenafil citrate was prescribed at doses of 25 or 50 mg depending on baseline creatinine values and on the response, and plasma levels of cyclosporin/FK506 were monitored. Results Thirty patients (60%) had a satisfactory response, with a mean time on dialysis of 23 months. Six patients (12%) did not take the sildenafil and in 14 (28%) the drug was ineffective. The mean time on dialysis in thisgroup was 43 months. Six patients (12%) had side-effects that in no case led to withdrawal of treatment. Plasma levels of cyclosporin/FK506 remained within the safety and efficacy limits in all patients. Conclusions Treatment with sildenafil citrate in renal transplant patientswith erectile dysfunction is an effective and safe option, with few side-effects. Plasma levels of immunosuppressants are unchanged. The response wasmore effective in patients with a shorter time on dialysis, as penile vascular disease is less advanced.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 12:24:20