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Titolo:
Cimetidine in painful bladder syndrome: a histopathological study
Autore:
Dasgupta, P; Sharma, SD; Womack, C; Blackford, HN; Dennis, P;
Indirizzi:
Edith Cavell Hosp, Peterborough Hosp NHS Trust, Dept Urol, Peterborough, Cambs, England Edith Cavell Hosp Peterborough Cambs England eterborough, Cambs, England Edith Cavell Hosp, Peterborough Hosp NHS Trust, Dept Pathol, Peterborough,Cambs, England Edith Cavell Hosp Peterborough Cambs England Peterborough,Cambs, England
Titolo Testata:
BJU INTERNATIONAL
fascicolo: 3, volume: 88, anno: 2001,
pagine: 183 - 186
SICI:
1464-4096(200108)88:3<183:CIPBSA>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
PIG URINARY-BLADDER; INTERSTITIAL CYSTITIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Dasgupta, P 9 Alma Sq,St Johns Wood, London NW8 9QD, England 9 Alma Sq,StJohns Wood London England NW8 9QD 9QD, England
Citazione:
P. Dasgupta et al., "Cimetidine in painful bladder syndrome: a histopathological study", BJU INT, 88(3), 2001, pp. 183-186

Abstract

Objective To determine whether oral cimetidine. which reportedly improves symptoms in 60-70% of patients with painful bladder syndrome/interstitial cystitis has a similar mechanism of action on the human bladder and involving a similar peptidergic pathway as it has in human stomach, where it altershistamine-gastrin reactions mediated via H-2 receptors and a proton pump. Patients and methods Fourteen patients (13 women and one man, mean age 51 years) with refractory bladder pain and irritative urinary symptoms were treated with cimetidine. The response to cimetidine was assessed by outpatient follow-up and an analogue pain score. Bladder biopsies from eight patients were stained with haematoxylin and eosin, and a polyclonal antibody to gastrin, with counterstaining using toluidine blue, to detect mast cell granules containing histamine. Biopsies from normal areas of the bladder from anage-matched control group of patients with transitional cell carcinoma of the bladder were stained similarly. Human stomach and colon were used as positive controls for gastrin and toluidine blue, respectively. The clinical response to cimetidine was compared with the histology in a blinded fashion. Results Eight of the patients responded well to cimetidine: none of the biopsies showed evidence of carcinoma in situ. Although G cells in the stomach stained well for gastrin none of the bladder biopsies showed gastrin-likeimmunoreactivity, apart from some non-specific urothelial staining. Numerous mast cells with crimson granules and pale nuclei were visible in three patients and fewer in three others: their presence or absence did not correlate with the symptomatic response. Conclusions Cimetidine is a useful medical treatment for bladder pain but the presence or absence of gastrin or histamine-like immunoreactivity does not explain its therapeutic benefit.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/07/20 alle ore 07:26:44