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Titolo:
Assessment of effects of experimental imprecision on optimized biochemicalsystems
Autore:
Voit, EO; Del Signore, M;
Indirizzi:
Med Univ S Carolina, Dept Biometry & Epidemiol, Charleston, SC 29425 USA Med Univ S Carolina Charleston SC USA 29425 iol, Charleston, SC 29425 USA
Titolo Testata:
BIOTECHNOLOGY AND BIOENGINEERING
fascicolo: 5, volume: 74, anno: 2001,
pagine: 443 - 448
SICI:
0006-3592(20010905)74:5<443:AOEOEI>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
METABOLIC REACTION NETWORKS; CITRIC-ACID ACCUMULATION; ASPERGILLUS-NIGER; CARBOHYDRATE-METABOLISM; STEADY-STATE; BIOTECHNOLOGICAL PROCESSES; SACCHAROMYCES-CEREVISIAE; SYNERGISM ANALYSIS; MODELING APPROACH; MAXIMIZATION;
Keywords:
biochemical systems; metabolic pathways; Monte Carlo simulation; optimization; S-systems;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Voit, EO Med Univ S Carolina, Dept Biometry & Epidemiol, Charleston, SC 29425 USA Med Univ S Carolina Charleston SC USA 29425 leston, SC 29425 USA
Citazione:
E.O. Voit e M. Del Signore, "Assessment of effects of experimental imprecision on optimized biochemicalsystems", BIOTECH BIO, 74(5), 2001, pp. 443-448

Abstract

Metabolic pathways may be optimized with S-system models that prescribe profiles of control variables leading to optimal output while keeping metabolites and enzyme activities within predefined ranges. Monte Carlo simulations show how much the yield and the corresponding metabolite concentrations would be affected by inaccuracies in the experimental implementation of the prescribed profiles. For a recent model of citric acid production in Aspergillus niger, the yield is roughly normally distributed, whereas the distributions of metabolite concentrations differ greatly in shape and statisticalcharacteristics. Even moderate inaccuracies may lead to constraint violations, which appear to be correlated with high logarithmic gains. (C) 2001 John Wiley & Sons, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 06:35:43