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Titolo:
Clinical and neurochemical effect of acute tryptophan depletion in unaffected relatives of patients with bipolar affective disorder
Autore:
Quintin, P; Benkelfat, C; Launay, JM; Arnulf, I; Pointereau-Bellenger, A; Barbault, S; Alvarez, JC; Varoquaux, O; Perez-Diaz, F; Jouvent, R; Leboyer, M;
Indirizzi:
Hop Albert Chenevier & Henri Mondor, Psychiat Serv, AP HP, F-94000 Creteil, France Hop Albert Chenevier & Henri Mondor Creteil France F-94000 eteil, France McGill Univ, Dept Psychiat, Montreal, PQ, Canada McGill Univ Montreal PQ Canada Univ, Dept Psychiat, Montreal, PQ, Canada Hop Henri Mondor, INSERM U513, F-94010 Creteil, France Hop Henri Mondor Creteil France F-94010 RM U513, F-94010 Creteil, France Hop Lariboisiere, Serv Biochim, CR C Bernard Pathol Expt & Commun Cellulaires, IFR 6,AP HP, F-75475 Paris, France Hop Lariboisiere Paris France F-75475 IFR 6,AP HP, F-75475 Paris, France Hop La Pitie Salpetriere, Ctr Invest Clin, AP HP, Paris, France Hop La Pitie Salpetriere Paris France Invest Clin, AP HP, Paris, France Hop La Pitie Salpetriere, Pharm Cent, AP HP, Paris, France Hop La Pitie Salpetriere Paris France Pharm Cent, AP HP, Paris, France Hop La Pitie Salpetriere, CNRS UMR 7593, AP HP, Paris, France Hop La PitieSalpetriere Paris France RS UMR 7593, AP HP, Paris, France Hop Mignot, Serv Pharmacol, Versailles, France Hop Mignot Versailles France Mignot, Serv Pharmacol, Versailles, France
Titolo Testata:
BIOLOGICAL PSYCHIATRY
fascicolo: 3, volume: 50, anno: 2001,
pagine: 184 - 190
SICI:
0006-3223(20010801)50:3<184:CANEOA>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEROTONIN TRANSPORTER GENE; MAJOR AFFECTIVE-DISORDER; POSSIBLE ASSOCIATION; PLASMA TRYPTOPHAN; RAPID DEPLETION; MOOD; DEPRESSION; SUSCEPTIBILITY; POLYMORPHISM; UNIPOLAR;
Keywords:
tryptophan depletion; bipolar affective disorder; unaffected relatives; serotonin transporter; endophenotype;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Leboyer, M Hop Albert Chenevier & Henri Mondor, Psychiat Serv, AP HP, 40 Rue Mesly, F-94000 Creteil, France Hop Albert Chenevier & Henri Mondor 40 Rue Mesly Creteil France F-94000
Citazione:
P. Quintin et al., "Clinical and neurochemical effect of acute tryptophan depletion in unaffected relatives of patients with bipolar affective disorder", BIOL PSYCHI, 50(3), 2001, pp. 184-190

Abstract

Background: The lowering of mood induced by an acute tryptophan depletion (ATD) has been proposed cis a candidate endophenotype for the vulnerabilityto manic-depressive illness. This study tests this hypothesis in relativesof probands from well-characterized multiplex families affected with bipolar affective disorder (BAD). Methods: In a double-blind, crossover design, 20 unaffected relatives (URs) and 19 control subjects received either a 100-g amino acid (AA) drink devoid of tryptophan or a placebo, respectively. Clinical and biochemical effects of ATD were compared between unaffected relatives of BAD probands and age- and sex-matched control subjects. Results: At 5 hours after AA drink ingestion, relative to the placebo, ATDresulted in 74% and 84%, decreases in total plasma tryptophan concentrations in control subjects and relatives of patients with BAD, respectively. Unlike control subjects unaffected relatives experienced a lowering of mood during ATD but not with the placebo. Furthermore, URs tended to show increased impulsivity in the ATD condition. Measurements obtained before ingestionof the AA drink indicated that, relative to control subjects URs exhibitedlower serotonin platelet concentrations, lower affinity and fewer binding sites of the serotonin transporter for imipramine; these differences it-ereunaffected by ATD. Conclusion: These results replicate and extend previous findings suggesting that URs of patients with BAD are more susceptible to low tryptophan availability. This finding mm, bear significance in the purported role of serotonergic mechanisms in the vulnerability, to depressive syndrome and/or illness. (C) 2001 Society of Biological Psychiatry.

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Documento generato il 31/03/20 alle ore 04:29:19