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Titolo:
Evidence of white matter tract disruption in MRI hyperintensities
Autore:
Taylor, WD; Payne, ME; Krishnan, KRR; Wagner, HR; Provenzale, JM; Steffens, DC; MacFall, JR;
Indirizzi:
Duke Univ, Med Ctr, Dept Psychiat, Durham, NC 27710 USA Duke Univ Durham NC USA 27710 ed Ctr, Dept Psychiat, Durham, NC 27710 USA Duke Univ, Dept Radiol, Durham, NC 27710 USA Duke Univ Durham NC USA 27710 uke Univ, Dept Radiol, Durham, NC 27710 USA Duke Univ, Neuropsychiat Imaging Res Lab, Durham, NC 27710 USA Duke Univ Durham NC USA 27710 chiat Imaging Res Lab, Durham, NC 27710 USA
Titolo Testata:
BIOLOGICAL PSYCHIATRY
fascicolo: 3, volume: 50, anno: 2001,
pagine: 179 - 183
SICI:
0006-3223(20010801)50:3<179:EOWMTD>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
APPARENT DIFFUSION-COEFFICIENT; CEREBROVASCULAR RISK-FACTORS; ACUTE STROKE; TENSOR MRI; TIME-COURSE; RESONANCE; DEPRESSION; LEUKOENCEPHALOPATHY; DAMAGE; SERIAL;
Keywords:
hyperintensities; neuroimaging; diffusion-weighted imaging; diffusion tensor imaging; depressive disorder; magnetic resonance imaging;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Taylor, WD Duke Univ, Med Ctr, Dept Psychiat, DUMC 3903, Durham, NC 27710 USA Duke Univ DUMC 3903 Durham NC USA 27710 3, Durham, NC 27710 USA
Citazione:
W.D. Taylor et al., "Evidence of white matter tract disruption in MRI hyperintensities", BIOL PSYCHI, 50(3), 2001, pp. 179-183

Abstract

Background: Diffusion tensor imaging (DTI) of brain tissue measures the apparent diffusion coefficient (ADC), or isotropic diffusion, and anisotropy,or diffusion as influenced by tissue structure. We hypothesized that hyperintensities, when compared with normal tissue by DTI, would show evidence of damage through an increased ADC and decreased anisotropy. We also hypothesized that DTI changes in hyperintensities would be similar between depressed subjects and control subjects. Methods: Fourteen depressed geriatric patients and nineteen control subjects received DTI. The ADC and anisotropy of normal tissue from standard regions were compared with hyperintensities from these regions. The Students' ttest compared individual regions and averaged white matter results. Results: Hyperintensities showed higher ADC and lower anisotropy than normal regions. Gray matter exhibited similar trends. There was no significant difference in diffusion characteristics of hyperintensities between subjects and control subjects. Conclusions: Hyperintensities damage the structure Of brain tissue, and doso comparably in depressed subjects and control subjects. (C) 2001 Societyof Biological Psychiatry.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 10:01:54