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Titolo:
Is attention-deficit/hyperactivity disorder an energy deficiency syndrome?
Autore:
Todd, RD; Botteron, KN;
Indirizzi:
Washington Univ, Sch Med, Dept Psychiat & Genet, St Louis, MO 63110 USA Washington Univ St Louis MO USA 63110 iat & Genet, St Louis, MO 63110 USA Washington Univ, Sch Med, Dept Radiol, St Louis, MO 63110 USA Washington Univ St Louis MO USA 63110 Dept Radiol, St Louis, MO 63110 USA
Titolo Testata:
BIOLOGICAL PSYCHIATRY
fascicolo: 3, volume: 50, anno: 2001,
pagine: 151 - 158
SICI:
0006-3223(20010801)50:3<151:IADAED>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASOACTIVE-INTESTINAL-PEPTIDE; EMISSION COMPUTED-TOMOGRAPHY; CEREBRAL GLUCOSE-METABOLISM; HYPERACTIVITY DISORDER; CHILDHOOD DISORDERS; LEARNING-DISABILITIES; DOPAMINE TRANSPORTER; CORTICAL ASTROCYTES; MAGNETIC-RESONANCE; BRAIN METABOLISM;
Keywords:
ADHD; catecholamines; astrocytes; prefrontal cortex; lactate; glycogenolysis;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Todd, RD Washington Univ, Sch Med, Dept Psychiat & Genet, 660 So Euclid Ave,Campus Box 8134, St Louis, MO 63110 USA Washington Univ 660 So Euclid Ave,Campus Box 8134 St Louis MO USA 63110
Citazione:
R.D. Todd e K.N. Botteron, "Is attention-deficit/hyperactivity disorder an energy deficiency syndrome?", BIOL PSYCHI, 50(3), 2001, pp. 151-158

Abstract

Attention-deficit/hyperactivity disorder (ADHD) is a highly heritable yet clinically heterogeneous syndrome associated with hypocatecholamine function in subcortical and prefrontal cortical regions and clinical response to medications that enhance catecholamine function. The goal of this article isto present a hypothesis about the etiology of ADHD by synthesizing these findings with recent experiments indicating that activity-dependent neuronalenergy consumption is regulated by cortical astrocytes. The scientific literature was searched from 1966 to the present using MEDLINE and relevant key words. Inattention and impulsivity may be related to hypofunctionality ofcatecholamine projection pathways to prefrontal cortical areas, resulting it? decreased neuronal energy availability. This may be mediated by astrocyte catecholamine receptors that normally regulate energy availability during neuronal activation. At least some forms of ADHD may be viewed as cortical, energy-deficit syndromes secondary to catecholamine-mediated hypofunctionality of astrocyte glucose and glycogen metabolism, which provides activity-dependent energy to cortical neurons. Several tests of this hypothesis are proposed. (C) 2001 Society of Biological Psychiatry.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 13:23:18