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Titolo:
Disseminated intravascular coagulation
Autore:
Letsky, EA;
Indirizzi:
Queen Charlottes Matern Hosp, Imperial Coll, Sch Med, Hammersmith Hosp Trust, London W12 0HS, England Queen Charlottes Matern Hosp London England W12 0HS don W12 0HS, England
Titolo Testata:
BEST PRACTICE & RESEARCH IN CLINICAL OBSTETRICS & GYNAECOLOGY
fascicolo: 4, volume: 15, anno: 2001,
pagine: 623 - 644
SICI:
1521-6934(200108)15:4<623:DIC>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMNIOTIC-FLUID EMBOLISM; THROMBOTIC THROMBOCYTOPENIC PURPURA; MASSIVE OBSTETRIC HEMORRHAGE; FACTOR-CLEAVING PROTEASE; PLACENTA-PREVIA-ACCRETA; ABRUPTIO PLACENTAE; ARTERIAL EMBOLIZATION; GROWTH-RETARDATION; CESAREAN-SECTION; NORMAL-PREGNANCY;
Keywords:
haemostatis; coagulopathy; fibrinolysis; massive haemorrhage; transfusion; abruptio placentae; amniotic fluid embolism; low-grade DIC; pre-eclampsia; sepsis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
90
Recensione:
Indirizzi per estratti:
Indirizzo: Letsky, EA Queen Charlottes Matern Hosp, Imperial Coll, Sch Med, Hammersmith Hosp Trust, Hammersmith House,2nd Floor,Du Cane Rd, London W12 0HS, England Queen Charlottes Matern Hosp Hammersmith House,2nd Floor,Du Cane Rd London England W12 0HS
Citazione:
E.A. Letsky, "Disseminated intravascular coagulation", BEST P R CL, 15(4), 2001, pp. 623-644

Abstract

Healthy pregnancy is accompanied by changes in the haemostatic system which convert it into a hypercoagulable state vulnerable to a spectrum of disorders ranging from venous thromboembolism to disseminated intravascular coagulation (DIC). This latter is always a secondary phenomenon triggered by specific disorders such as abruptio placentae and amniotic fluid embolism dueto release of thromboplastin intravascularly or endothelial damage resulting from pre-eclampsia and sepsis. In modern obstetric practice the most common cause is haemorrhagic shock with delay in resuscitation leading to endothelial damage. The initial management of massive obstetric haemorrhage is the same whether associated with coagulopathy initially or not. Low-grade DIC, associated with pre-eclampsia, is monitored haematologically by serial platelet counts and serum fibrin degradation products (FDPs). Supportive measures and removal of the triggering mechanism are the key to successful management. Outcome depends primarily on our ability to deal with the triggerand not on direct attempts to correct the coagulation deficit.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 04:57:12