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Titolo:
Effects of benztropine on ketamine-induced behaviors in Cebus monkeys
Autore:
Shiigi, Y; Casey, DE;
Indirizzi:
Vet Affairs Med Ctr, Mental Illness Res Educ & Clin Ctr, Mental Hlth Div P3MHDC, Portland, OR 97201 USA Vet Affairs Med Ctr Portland OR USA 97201 P3MHDC, Portland, OR 97201 USA Welfide Corp, Res Labs, Iruma, Saitama, Japan Welfide Corp Iruma Saitama Japan e Corp, Res Labs, Iruma, Saitama, Japan Oregon Reg Primate Res Ctr, Beaverton, OR 97006 USA Oregon Reg Primate ResCtr Beaverton OR USA 97006 Beaverton, OR 97006 USA Oregon Hlth Sci Univ, Dept Psychiat, Portland, OR 97201 USA Oregon Hlth Sci Univ Portland OR USA 97201 ychiat, Portland, OR 97201 USA Oregon Hlth Sci Univ, Dept Neurol, Portland, OR 97201 USA Oregon Hlth Sci Univ Portland OR USA 97201 Neurol, Portland, OR 97201 USA
Titolo Testata:
BEHAVIOURAL PHARMACOLOGY
fascicolo: 4, volume: 12, anno: 2001,
pagine: 293 - 298
SICI:
0955-8810(200107)12:4<293:EOBOKB>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXTRAPYRAMIDAL SYNDROMES; NMDA ANTAGONIST; PHENCYCLIDINE; SCHIZOPHRENIA; ACETYLCHOLINE; CLOZAPINE; DYSTONIA; MODEL; DYSFUNCTION; OLANZAPINE;
Keywords:
ketamine; benztropine; NMDA; anticholinergics; nonhuman primates; behavior; Cebus monkey;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Casey, DE Vet Affairs Med Ctr, Mental Illness Res Educ & Clin Ctr, Mental Hlth Div P3MHDC, 3710 SW US Vet Hosp Rd, Portland, OR 97201 USA Vet AffairsMed Ctr 3710 SW US Vet Hosp Rd Portland OR USA 97201
Citazione:
Y. Shiigi e D.E. Casey, "Effects of benztropine on ketamine-induced behaviors in Cebus monkeys", BEHAV PHARM, 12(4), 2001, pp. 293-298

Abstract

Ketamine, a noncompetitive N-methyl-D-aspartate (NMDA) glutamate receptor antagonist, causes a schizophrenic-like psychosis in normal volunteers and exacerbates psychotic symptoms in patients with schizophrenia. Recent work has shown that ketamine and other NMDA antagonists affect a range of behaviors in nonhuman primates, particularly those associated with motor and mental function such as attention and perception. Several lines of study also suggest that NMDA antagonists interact with cholinergic mechanisms. The effects of benztropine, an anticholinergic agent, on ketamine-induced behaviorswere evaluated in a double-blind randomized test design in 20 Cebus monkeys. Benztropine (0.05, 0.1 and 0.25 mg/kg, i.m.) was injected 1 hour before ketamine (2.5 and 5.0 mg/kg, i.m.) administration. Behaviors scored for 90 minutes after ketamine administration included salivation, dystonia and reactivity to external stimuli. Benztropine almost completely blocked ketamine-induced hypersalivation, and partially ameliorated the dystonia syndrome by 50%, but did not affect ketamine-induced decreased reactivity to externalstimuli. These results suggest that cholinergic mechanisms only moderatelyinfluence ketamine-induced central nervous system effects of motor dysfunction, and may not play a substantive role in the ketamine-induced deficit of reactivity to external stimuli, which involves a complex interaction of mental functions such as attention and perception, as well as motor behavior. (C) 2001 Lippincott Williams & Wilkins.

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Documento generato il 25/01/20 alle ore 18:46:07