Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Individual differences in behavioral responses to novelty and amphetamine self-administration in male and female rats
Autore:
Klebaur, JE; Bevins, RA; Segar, TM; Bardo, MT;
Indirizzi:
Univ Michigan, Dept Psychol, Ann Arbor, MI USA Univ Michigan Ann Arbor MIUSA Michigan, Dept Psychol, Ann Arbor, MI USA Univ Michigan, Program Neurosci, Ann Arbor, MI USA Univ Michigan Ann Arbor MI USA igan, Program Neurosci, Ann Arbor, MI USA Univ Nebraska, Dept Psychol, Lincoln, NE 68588 USA Univ Nebraska Lincoln NE USA 68588 a, Dept Psychol, Lincoln, NE 68588 USA Univ Kentucky, Dept Psychol, Lexington, KY 40506 USA Univ Kentucky Lexington KY USA 40506 ept Psychol, Lexington, KY 40506 USA
Titolo Testata:
BEHAVIOURAL PHARMACOLOGY
fascicolo: 4, volume: 12, anno: 2001,
pagine: 267 - 275
SICI:
0955-8810(200107)12:4<267:IDIBRT>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONDITIONED PLACE PREFERENCE; ELICITED ROTATIONAL BEHAVIOR; SEX-DIFFERENCES; PLAYGROUND MAZE; COCAINE; PREDICT; SENSITIZATION; VULNERABILITY; ACQUISITION; DOPAMINE;
Keywords:
individual differences; novelty; locomotor activity; amphetamine; self-administration; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Bardo, MT 115 Kastle Hall, Lexington, KY 40506 USA 115 Kastle Hall Lexington KY USA 40506 Lexington, KY 40506 USA
Citazione:
J.E. Klebaur et al., "Individual differences in behavioral responses to novelty and amphetamine self-administration in male and female rats", BEHAV PHARM, 12(4), 2001, pp. 267-275

Abstract

Previous work has shown that individual differences in locomotor activity in an inescapable novel environment can predict acquisition of amphetamine self-administration. The current study examined whether individual differences in approach to novelty in a free choice test could also predict amphetamine self-administration. Further, the current study examined whether individual differences in either free choice or inescapable novelty tests could predict responding for a nondrug reinforcer (sucrose) in the presence and absence of amphetamine. Male and female rats were first tested for their response to free choice novelty, (playground maze and novelty-induced place preference tests) and inescapable novelty. They were then tested for acquisition of sucrose-reinforced responding, am phetamine-induced changes in maintenance of sucrose-reinforced responding, and amphetamine self-administration. Based on the inescapable novelty test, acquisition of sucrose-reinforcedresponding was more rapid in male high responders (HR) compared to low responders (LR). This effect in males did not generalize to females. None of the novelty tests predicted the ability of amphetamine to decrease sucrose-maintained responding. However, using the inescapable novelty test, both male and female HRs self-administered more amphetamine than LRs within the dose range tested (0.03-0.16 mg/kg/infusion). Neither the playground maze nor the novelty-induced place preference test predicted amphetamine self-administration. These results indicate that responses to free choice novelty and inescapable novelty predict different components of amphetamine-induced behavior. (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 12:17:19