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Titolo:
High rates of midazolam self-administration in squirrel monkeys
Autore:
Munzar, P; Yasar, S; Redhi, GH; Justinova, Z; Goldberg, SR;
Indirizzi:
NIDA, Preclin Pharmacol Sect, Behav Neurosci Branch, Intramural Res Program,NIH, Baltimore, MD 21224 USA NIDA Baltimore MD USA 21224 ural Res Program,NIH, Baltimore, MD 21224 USA Johns Hopkins Univ, Sch Med, Div Geriatr Med & Gerontol, Baltimore, MD USAJohns Hopkins Univ Baltimore MD USA tr Med & Gerontol, Baltimore, MD USA
Titolo Testata:
BEHAVIOURAL PHARMACOLOGY
fascicolo: 4, volume: 12, anno: 2001,
pagine: 257 - 265
SICI:
0955-8810(200107)12:4<257:HROMSI>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
RHESUS-MONKEY; FIXED-RATIO; BENZODIAZEPINES; INJECTION; BABOONS; SCHEDULES; BEHAVIOR; NICOTINE; ABUSE;
Keywords:
midazolam; methohexital; self-administration; squirrel monkey;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Goldberg, SR NIDA, Preclin Pharmacol Sect, Behav Neurosci Branch, Intramural Res Program,NIH, 5500 Nathan Shock Dr, Baltimore, MD 21224 USA NIDA 5500Nathan Shock Dr Baltimore MD USA 21224 MD 21224 USA
Citazione:
P. Munzar et al., "High rates of midazolam self-administration in squirrel monkeys", BEHAV PHARM, 12(4), 2001, pp. 257-265

Abstract

Although benzodiazepines are frequently abused by humans, they usually maintain lower rates of self-administration behavior in laboratory animals than other drugs of abuse such as psychomotor stimulants or barbiturates. In the present study, intravenous (i.v.) self-administration of the short-acting benzodiazepine midazolam was evaluated in squirrel monkeys. Monkeys (n = 3) initially self-administered the short-acting barbiturate methohexital (100 mug/kg/injection) during daily 1-hour sessions under a fixed-ratio 10, 60s time-out, schedule of i.v. drug injection. This dose of methohexital maintained high rates of responding averaging 0.9 responses per second. Midazolam was then substituted for methohexital, and midazolam dose was subsequently varied from 0.3 to 3 mug/kg/injection. Each dose of midazolam was tested for five consecutive sessions and each unit dose condition was separated by five sessions of vehicle extinction. The midazolam dose-response function was an inverted U-shaped curve, with maximal rates of self-administrationresponding averaging 1.01 responses/second at a dose of 1 mug/kg/injection(an average of 48 injections per 1-hour session). The rates and fixed-ratio patterns of responding maintained by self-administration of midazolam in the present study were comparable to the rates and patterns of responding maintained in squirrel monkeys by self-administration of other drugs of abuse, including cocaine, amphetamine, nicotine and tetrahydrocannabinol, undersimilar experimental conditions. (C) 2001 Lippincott Williams & Wilkins.

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Documento generato il 19/01/20 alle ore 09:48:28