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Titolo:
Cocaine-like discriminative stimulus effects and [H-3]dopamine uptake inhibition produced by selected partial opioid agonists
Autore:
Barrett, AC; Morgan, D; Izenwasser, S; Picker, MJ;
Indirizzi:
Univ N Carolina, Dept Psychol, Chapel Hill, NC 27599 USA Univ N Carolina Chapel Hill NC USA 27599 ychol, Chapel Hill, NC 27599 USA Wake Forest Univ, Bowman Gray Sch Med, Dept Physiol & Pharmacol, Winston Salem, NC 27103 USA Wake Forest Univ Winston Salem NC USA 27103 , Winston Salem, NC 27103 USA Univ Miami, Sch Med, Dept Neurol, Miami, FL USA Univ Miami Miami FL USAUniv Miami, Sch Med, Dept Neurol, Miami, FL USA
Titolo Testata:
BEHAVIOURAL PHARMACOLOGY
fascicolo: 4, volume: 12, anno: 2001,
pagine: 225 - 235
SICI:
0955-8810(200107)12:4<225:CDSEA[>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOPAMINE TRANSPORTER AFFINITIES; SQUIRREL-MONKEYS; INTRINSIC EFFICACY; RHESUS-MONKEYS; D-AMPHETAMINE; PHARMACOLOGICAL CHARACTERIZATION; SUBSTITUTION PATTERNS; MEPERIDINE; MORPHINE; RATS;
Keywords:
partial opioid agonists; [H-3]dopamine uptake; cocaine; rat; non-opioid; drug discrimination;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Barrett, AC Univ N Carolina, Dept Psychol, CB 3270, Chapel Hill, NC 27599 USA Univ N Carolina CB 3270 Chapel Hill NC USA 27599 NC 27599 USA
Citazione:
A.C. Barrett et al., "Cocaine-like discriminative stimulus effects and [H-3]dopamine uptake inhibition produced by selected partial opioid agonists", BEHAV PHARM, 12(4), 2001, pp. 225-235

Abstract

Partial opioid agonists can produce their actions at opioid as well as some non-opioid sites. Although the receptor systems underlying these non-opioid effects are not completely clear, recent studies indicate the possible involvement of activity at the dopamine uptake site. One purpose of the present investigation was to examine the ability of selected partial opioid agonists (dezocine, meperidine and [+]-propoxyphene) with non-opioid actions to produce cocaine-like stimulus effects. Because non-opioid effects can be apparent under conditions in which opioid-mediated effects are blocked or at doses that markedly decrease responding, these opioids were also examinedin combination with the opioid antagonist naltrexone. A second purpose wasto determine the ability of these opioids to inhibit [H-3] dopamine uptakein rat caudate putamen. Cocaine and the direct-acting dopamine agonist (-)-quinpirole, but not (+)-propoxyphene, butorphanol, morphine, U50,488 and pentobarbital, substituted completely for the cocaine stimulus. Dezocine substituted for the cocaine stimulus in the majority of the rats tested only when administered in combination with naltrexone. Meperidine also substituted for the cocaine stimulus in the majority of the rats tested, although this pattern of substitution was not consistently altered by naltrexone. Dezocine and meperidine inhibited [H-3] dopamine uptake in a manner consistent with that produced by cocaine. The results suggest that dezocine and meperidine can produce cocaine-like stimulus effects and that these effects are likely mediated by activity at the dopamine uptake site. (C) 2001 Lippincott Williams & Wilkins.

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Documento generato il 02/04/20 alle ore 19:13:02