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Titolo:
Hemorrhage activates catecholaminergic neurons sensitive to GABA in the nucleus of the solitary tract with ascending projections to the subfornical organ in rats
Autore:
Tanaka, J; Miyakubo, H; Hayashi, Y; Nomura, M;
Indirizzi:
Naruto Univ Educ, Dept Human Dev, Tokushima 7728502, Japan Naruto Univ Educ Tokushima Japan 7728502 n Dev, Tokushima 7728502, Japan Naruto Univ Educ, Neurosci Program, Tokushima 7728502, Japan Naruto Univ Educ Tokushima Japan 7728502 ogram, Tokushima 7728502, Japan Dept Educ Handicapped Children, Tokushima 7728502, Japan Dept Educ Handicapped Children Tokushima Japan 7728502 ma 7728502, Japan Saitama Med Sch, Dept Physiol, Iruma, Saitama 3500495, Japan Saitama Med Sch Iruma Saitama Japan 3500495 Iruma, Saitama 3500495, Japan
Titolo Testata:
AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL
fascicolo: 1-2, volume: 91, anno: 2001,
pagine: 100 - 104
SICI:
1566-0702(20010813)91:1-2<100:HACNST>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
GAMMA-AMINOBUTYRIC ACID; ANGIOTENSIN-II; PARAVENTRICULAR NUCLEUS; BARORECEPTOR REFLEX; VASOPRESSIN RELEASE; PRESSOR-RESPONSES; BLOOD-PRESSURE; IDENTIFICATION; RECEPTOR; LESIONS;
Keywords:
nucleus of the solitary tract; subfornical organ; gamma-aminobutyric acid; bicuculline; microiontophoresis; hemorrhage; 6-hydroxydopan-line;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Tanaka, J Naruto Univ Educ, Dept Human Dev, Naruto Cho, Tokushima 7728502,Japan Naruto Univ Educ Naruto Cho Tokushima Japan 7728502 8502, Japan
Citazione:
J. Tanaka et al., "Hemorrhage activates catecholaminergic neurons sensitive to GABA in the nucleus of the solitary tract with ascending projections to the subfornical organ in rats", AUTON NEURO, 91(1-2), 2001, pp. 100-104

Abstract

The activity of neurons in the region of the nucleus of the solitary tract(NTS) that were antidromically identified by electrical stimulation of therat subfornical organ (SFO) was tested for a response to microiontophoretic application of gamma -aminobutyric acid (GABA), hemorrhage (10 ml/kg b.w.t.), or local administration of the chemical neurotoxin, 6-hydroxydopamine (6-OHDA), into the SFO stimulation site. Microiontophoretic ally (MIPh) applied GABA caused a decrease excitability in 22 out of 24 neurons tested, and the inhibition was blocked by MIPh-applied bicuculline, a GABA(A) antagonist, but not by phaclofen, a GABA(B) antagonist. Of these neurons that responded to GABA, 17 displayed an increase in neural firing in response to hemorrhage, while 5 were unresponsive. The occurrence of both antidromic spikes and post-stimulus inhibition of 9 out of 13 neurons tested was completelyabolished by the injection of 6-OHDA into the SFO. These results suggest that neurons in the region of the NTS, which carry peripheral baroreceptor information to the SFO, receive GABAergic inhibitory inputs via a GABA(A) receptor mechanism, and imply that part of these neurons are catecholaminergic. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 09:00:01