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Titolo:
Selective impairment of excitatory pressor responses after prolonged simulated microgravity in humans
Autore:
Pagani, M; Iellamo, F; Lucini, D; Cerchiello, M; Castrucci, F; Pizzinelli, P; Porta, A; Malliani, A;
Indirizzi:
Univ Milan, Dipartimento Med Interna, CNR, Ctr Ric Cardiovasc, I-20157 Milan, Italy Univ Milan Milan Italy I-20157 Ctr Ric Cardiovasc, I-20157 Milan, Italy Univ Roma Tor Vergata, Dipartimento Med Interna, Osped S Eugenio, Rome, Italy Univ Roma Tor Vergata Rome Italy Interna, Osped S Eugenio, Rome, Italy Univ Milan, Ctr Ric Terapia Neurovegetativa, Milan, Italy Univ Milan Milan Italy n, Ctr Ric Terapia Neurovegetativa, Milan, Italy Univ Milan, DiSP, Milan, Italy Univ Milan Milan ItalyUniv Milan, DiSP, Milan, Italy
Titolo Testata:
AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL
fascicolo: 1-2, volume: 91, anno: 2001,
pagine: 85 - 95
SICI:
1566-0702(20010813)91:1-2<85:SIOEPR>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOWN BED-REST; SYMPATHETIC-NERVE ACTIVITY; HEART-RATE-VARIABILITY; ORTHOSTATIC INTOLERANCE; AUTONOMIC REGULATION; SINUS NODE; NOREPINEPHRINE; SPACEFLIGHT; EXPOSURE; EXERCISE;
Keywords:
head down bed rest; autonomic nervous system; spectral analysis; baroreflex;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Pagani, M Univ Milan, Dipartimento Med Interna, CNR, Ctr Ric Cardiovasc, Via GB Grassi 74, I-20157 Milan, Italy Univ Milan Via GB Grassi 74 Milan Italy I-20157 57 Milan, Italy
Citazione:
M. Pagani et al., "Selective impairment of excitatory pressor responses after prolonged simulated microgravity in humans", AUTON NEURO, 91(1-2), 2001, pp. 85-95

Abstract

The haemodynamic and autonomic effects of prolonged exposure to simulated microgravity were assessed non-invasively in seven healthy volunteers completing a 42-day -6 degrees head down tilt. Before, during and after head down tilt, subjects were exposed to moderate excitatory stimuli (mental arithmetic and static handgrip) to gauge possible progressive impairment of pressor responses. Before and after head down tilt, subjects were also exposed to orthostatic stress, to assess influences of simulated microgravity on orthostatic defence. Simple haemodynamics (heart rate and systolic arterial blood pressure), linear (i.e., oscillatory) components of beat-by-beat variability, non-linear properties (i.e., corrected conditional entropy (CCE)) ofRR interval variability, and baroreflex slope furnished a non-invasive evaluation of autonomic regulatory mechanisms. Pressor responses to mental arithmetic and to handgrip were markedly impaired after 42 days head down tilt, whereas responses in markers of autonomic regulation were not modified. Standing, performed 8 days after head down tilt to limit the risk of syncope, still induced a variable degree of hypotension, with signs of progressively greater sympathetic activation than before head down tilt, Simulated microgravity-induced reduction of pressor responses, in spite of largely maintained autonomic activation, favours the hypothesis of a peripheral impairment of cardiovascular homeostasis. (C) 2001 Elsevier Science B.V. All rightsreserved.

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Documento generato il 09/04/20 alle ore 07:32:28