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Titolo:
A model for the genesis of arterial pressure Mayer waves from heart rate and sympathetic activity
Autore:
Myers, CW; Cohen, MA; Eckberg, DL; Taylor, JA;
Indirizzi:
Harvard Univ, Sch Med, Div Aging, HRCA Lab Cardiovasc Res, Boston, MA 02131 USA Harvard Univ Boston MA USA 02131 Lab Cardiovasc Res, Boston, MA 02131 USA Boston Univ, Dept Cognit & Neural Sci, Boston, MA 02115 USA Boston Univ Boston MA USA 02115 Cognit & Neural Sci, Boston, MA 02115 USA Hunter Holmes McGuire Vet Affairs Med Ctr, Richmond, VA 23249 USA Hunter Holmes McGuire Vet Affairs Med Ctr Richmond VA USA 23249 23249 USA Virginia Commonwealth Univ Med Coll Virginia, Richmond, VA 23249 USA Virginia Commonwealth Univ Med Coll Virginia Richmond VA USA 23249 49 USA
Titolo Testata:
AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL
fascicolo: 1-2, volume: 91, anno: 2001,
pagine: 62 - 75
SICI:
1566-0702(20010813)91:1-2<62:AMFTGO>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD-PRESSURE; BAROREFLEX SENSITIVITY; CRITICAL-APPRAISAL; SPECTRAL-ANALYSIS; CARDIOVASCULAR REGULATION; BARORECEPTOR REFLEX; NERVE ACTIVITY; RR-INTERVAL; HUMANS; OSCILLATIONS;
Keywords:
hemodynamics; spectral analysis; hydraulic resistance equation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Taylor, JA Harvard Univ, Sch Med, Div Aging, HRCA Lab Cardiovasc Res, Boston, MA 02131 USA Harvard Univ Boston MA USA 02131 asc Res, Boston, MA 02131 USA
Citazione:
C.W. Myers et al., "A model for the genesis of arterial pressure Mayer waves from heart rate and sympathetic activity", AUTON NEURO, 91(1-2), 2001, pp. 62-75

Abstract

Both theoretic models and cross-spectral analyses suggest that an oscillating sympathetic nervous outflow generates the low-frequency arterial pressure fluctuations termed Mayer waves. Fluctuations in heart rate also have been suggested to relate closely to Mayer waves, but empiric models have not assessed the joint causative influences of heart rate and sympathetic activity. Therefore, we constructed a model based simply upon the hemodynamic equation derived from Ohm's Law. With this model, we determined time relations and relative contributions of heart rate and sympathetic activity to the genesis of arterial pressure Mayer waves. We assessed data from eight healthy young volunteers in the basal state and in a high sympathetic state known to produce concurrent increases in sympathetic nervous outflow and Mayer wave amplitude. We fit the Mayer waves (0.05-0.20 Hz) in mean arterial pressure by the weighted sum of leading oscillations in heart rate and sympathetic nerve activity. This model of our data showed heart rate oscillations leading by 2-3.75 s were responsible for almost half of the variance in arterial pressure (basal R-2 = 0.435 +/- 0.140, high sympathetic R-2 = 0.438 +/- 0.180). Surprisingly, sympathetic activity (lead 0-5 s) contributed only modestly to the explained variance in Mayer waves during either sympatheticstate (basal: Delta R-2 = 0.046 +/- 0.026; heightened: DeltaR(2) = 0.085 +/- 0.036). Thus, it appears that heart rate oscillations contribute to Mayer waves in a simple linear fashion, whereas sympathetic fluctuations contribute little to Mayer waves in this way. Although these results do not exclude an important vascular sympathetic role, they do suggest that additional factors, such as sympathetic transduction into vascular resistance, modulate its influence. (C) 2001 Elsevier Science B.V. All rights reserved.

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Documento generato il 31/03/20 alle ore 21:26:32