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Titolo:
Neuromodulation therapy does not influence blood flow distribution or left-ventricular dynamics during acute myocardial ischemia
Autore:
Kingma, JG; Linderoth, B; Ardell, JL; Armour, JA; DeJongste, MJL; Foreman, RD;
Indirizzi:
Univ Laval, Dept Med, St Foy, PQ G1K 7P4, Canada Univ Laval St Foy PQ Canada G1K 7P4 Dept Med, St Foy, PQ G1K 7P4, Canada Karolinska Inst, Dept Neurosurg, SE-17176 Stockholm, Sweden Karolinska Inst Stockholm Sweden SE-17176 rg, SE-17176 Stockholm, Sweden E Tennessee State Univ, Dept Pharmacol, Johnson City, TN 37614 USA E Tennessee State Univ Johnson City TN USA 37614 hnson City, TN 37614 USA Dalhousie Univ, Dept Physiol & Biophys, Halifax, NS B3H 4H7, Canada Dalhousie Univ Halifax NS Canada B3H 4H7 hys, Halifax, NS B3H 4H7, Canada Univ Groningen Hosp, Dept Cardiol, Ctr Thorax, Groningen, Netherlands UnivGroningen Hosp Groningen Netherlands horax, Groningen, Netherlands Univ Oklahoma, Hlth Sci Ctr, Dept Physiol, Oklahoma City, OK 73190 USA Univ Oklahoma Oklahoma City OK USA 73190 iol, Oklahoma City, OK 73190 USA
Titolo Testata:
AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL
fascicolo: 1-2, volume: 91, anno: 2001,
pagine: 47 - 54
SICI:
1566-0702(20010813)91:1-2<47:NTDNIB>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPINAL-CORD STIMULATION; ELECTRICAL NERVE-STIMULATION; POSITRON EMISSION TOMOGRAPHY; REFRACTORY ANGINA-PECTORIS; INTRINSIC CARDIAC NEURONS; CORONARY-ARTERY; INTRACTABLE ANGINA; PRESSURE; VOLUME; MODULATION;
Keywords:
myocardium; blood flow; spinal cord; ischemia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Kingma, JG Univ Laval, Dept Med, St Foy, PQ G1K 7P4, Canada Univ Laval StFoy PQ Canada G1K 7P4 St Foy, PQ G1K 7P4, Canada
Citazione:
J.G. Kingma et al., "Neuromodulation therapy does not influence blood flow distribution or left-ventricular dynamics during acute myocardial ischemia", AUTON NEURO, 91(1-2), 2001, pp. 47-54

Abstract

Objectives. Electrical stimulation of the dorsal aspect of the upper thoracic spinal cord is used increasingly to treat patients with angina pectorisrefractory to conventional therapeutic strategies. The purpose of this study was to determine whether spinal cord stimulation (SCS) in dogs affects regional myocardial blood flow and left-ventricular (LV) function before andduring transient obstruction of the left anterior descending coronary artery (LAD). Methods. In anesthetized dogs, regional myocardial blood flow distribution was determined using radiolabeled microspheres and left-ventricular function was measured by impedance-derived pressure-volume loops. SCS was accomplished by stimulating the dorsal T1-T2 segments of the spinal cord using epidural bipolar electrodes at 90% of motor threshold (MT) (50 Hz, 0.2-ms duration). Effects of 5-min SCS were assessed under basal conditions and during 4-min occlusion of the LAD. Results. SCS alone evoked no change in regional myocardial blood flow or cardiovascular indices. Transient LAD occlusion significantly diminished blood flow within ischemic, but not in non-ischemic myocardial tissue. Left ventricular pressure-volume loops were shifted rightward during LAD occlusion. Cardiac indices were altered similarly during LAD occlusion and concurrent SCS. Conclusions. SCS does not influence the distribution of blood flow within the non-ischemic or ischemic myocardium. Nor does it modify LV pressure-volume dynamics in the anesthetizedexperimental preparation. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 16:56:16