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Titolo:
Urodynamic effects induced by intravesical capsaicin in rats and hamsters
Autore:
Lecci, A; Carini, F; Tramontana, M; Birder, LA; de Groat, WC; Santicioli, P; Giuliani, S; Maggi, CA;
Indirizzi:
Menarini Ric, Pharmacol Res Dept, I-50131 Florence, Italy Menarini Ric Florence Italy I-50131 ol Res Dept, I-50131 Florence, Italy Univ Pittsburgh, Dept Med, Renal Electrolyte Div, Pittsburgh, PA USA Univ Pittsburgh Pittsburgh PA USA al Electrolyte Div, Pittsburgh, PA USA Univ Pittsburgh, Dept Pharmacol, Pittsburgh, PA 15261 USA Univ PittsburghPittsburgh PA USA 15261 armacol, Pittsburgh, PA 15261 USA
Titolo Testata:
AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL
fascicolo: 1-2, volume: 91, anno: 2001,
pagine: 37 - 46
SICI:
1566-0702(20010813)91:1-2<37:UEIBIC>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENE-RELATED PEPTIDE; ISOLATED URINARY-BLADDER; MICTURITION REFLEX; VANILLOID RECEPTORS; FUNCTIONAL EVIDENCE; PERIPHERAL ENDINGS; SENSORY NEURONS; CONSCIOUS RATS; NK2 RECEPTORS; NEUROKININ-A;
Keywords:
VR1; micturition reflex; urinary bladder; nepadutant (MEN11420) CGRP;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Lecci, A Menarini Ric, Pharmacol Res Dept, Via Rismondo 12-A, I-50131 Florence, Italy Menarini Ric Via Rismondo 12-A Florence Italy I-50131 nce, Italy
Citazione:
A. Lecci et al., "Urodynamic effects induced by intravesical capsaicin in rats and hamsters", AUTON NEURO, 91(1-2), 2001, pp. 37-46

Abstract

This study compared the effect of acute intravesical capsaicin administration on transvesical cystometries in urethane-anesthetized rats and hamsters, and aimed to assess whether sensory neuropeptides (tachykinins; calcitonin gene-related peptide, CGRP) play a role in the urodynamic effects of capsaicin in these species. The following urodynamic parameters were evaluated:the mean micturition interval (MI), the pressure threshold for micturition(PT), and the mean amplitude of micturition contractions (MAC). Two concentrations of capsaicin (10 and 100 muM) were evaluated in both species. Here, we demonstrate that 10-muM capsaicin decreased the PT in both rats and hamsters, and 100-muM capsaicin decreased the PT in hamsters and decreased the MI in both species. In addition, 100-muM capsaicin increased the MAC in rats but decreased the MAC in hamsters. Administration of CGRP (10 nmol kg(-1), i.v.) significantly decreased both MAC and PT in hamsters only, while capsaicin-induced desensitization of neuropeptide-containing afferents antagonized the urodynamic effects of intravesical capsaicin. In addition, administration of the tachykinin N-K-2 receptor antagonist, Nepadutant (100 nmolkg(-1), i.v.), reduced the effects of capsaicin (100 muM) only in rats. These results indicate that capsaicin induces bladder hyperactivity in both rats and hamsters, but the urodynamic characteristics of this hyperactivity markedly differ in these two species. The differences observed may be due to differential expression of sensory neuropeptides in capsaicin-sensitive bladder afferents or neuropeptide receptors in smooth muscle cells and in nerve fibers. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 11:51:09