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Titolo:
Moxonidine reduces pilocarpine-induced salivation in rats
Autore:
Moreira, TS; Takakura, ACT; De Luca, LA; Renzi, A; Menani, JV;
Indirizzi:
Paulista State Univ UNESP, Dept Physiol & Pathol, Sch Dent, BR-14801903 Araraquara, SP, Brazil Paulista State Univ UNESP Araraquara SP Brazil BR-14801903 BC, SP, Brazil
Titolo Testata:
AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL
fascicolo: 1-2, volume: 91, anno: 2001,
pagine: 32 - 36
SICI:
1566-0702(20010813)91:1-2<32:MRPSIR>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPONTANEOUSLY HYPERTENSIVE RATS; ANTIHYPERTENSIVE AGENT; BLOOD-PRESSURE; CLONIDINE; SECRETION; DRUGS;
Keywords:
adrenergic and imidazoline receptors; salivary secretion; parasympathetic; moxonidine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Moreira, TS Paulista State Univ UNESP, Dept Physiol & Pathol, Sch Dent, Rua Humaita 1680, BR-14801903 Araraquara, SP, Brazil Paulista State Univ UNESP Rua Humaita 1680 Araraquara SP Brazil BR-14801903 BC
Citazione:
T.S. Moreira et al., "Moxonidine reduces pilocarpine-induced salivation in rats", AUTON NEURO, 91(1-2), 2001, pp. 32-36

Abstract

Cholinergic, agonists activate salivation and the alpha (2)-adrenergic andimidazoline receptor agonists induce opposite effects. In the present study, we investigated the effects of intracerebroventricular (i.c.v.) or intraperitoneal (i.p.) injection of moxonidine (an a-adrenergic and imidazoline receptor agonist) on the salivation induced by the cholinergic agonist pilocarpine. Male Holtzman rats wish stainless steel cannula implanted into thelateral ventricle (LV) were used. In rats anesthetized with tribromoethanol (200 mg kg(-1)), saliva was collected using pre-weighed small cotton balls inserted in the animal's mouth. The treatment with moxonidine (5, 10 and 20 nmol in 1 mul) injected,i.c.v. reduced the salivation induced by pilocarpine (1 mg kg(-1)) injected i.p. (48 +/- 5, 17 +/- 2 and 15 +/- 2 mg min(-1) vs. control, 73 +/- 7 mg min(-1)). The same doses of moxonidine injected i.c.v. also reduced the salivary secretion induced by pilocarpine (500 nmolin 1 mul). injected i.c.v. (44 +/- 1, 14 +/- 2 and 20 +/- 3 mg min(-1) vs.control, 51 +/- 2 mg min(-1)). Injection of moxonidine (20 nmol in 0.1 ml)i.p. produced no chance on i.p. pilocarpine-induced salivation (58 +/- 4 mg min(-1) vs. control, 50 +/- 4 mg min(-1)). The results show that central,but not peripheral, injection of moxonidine inhibit,. pilocarpine-induced salivation, suggesting that central mechanisms activated by alpha (2)-adrenergic/imidazoline agonists inhibit cholinergic-induced salivation in rats. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 02:29:21