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Titolo:
Analysis of the relationship between triglyceridemia and HDL-phospholipid concentrations: consequences on the efflux capacity of serum in the Fu5AH system
Autore:
Fournier, N; Atger, W; Cogny, A; Vedie, B; Giral, P; Simon, A; Moatti, N; Paul, JL;
Indirizzi:
Fac Sci Pharmaceut & Biol Chatenay Malabry, Lab Biochim Appliquee, Chatenay Malabry, France Fac Sci Pharmaceut & Biol Chatenay Malabry Chatenay Malabry France ance Hop Europeen Georges Pompidou, Biochim Lab, F-75908 Paris 15, France Hop Europeen Georges Pompidou Paris France 15 , F-75908 Paris 15, France Hop La Pitie Salpetriere, Lab Endocrinol, AP HP, Paris, France Hop La Pitie Salpetriere Paris France Endocrinol, AP HP, Paris, France Hop Broussais, Ctr Med Prevent Cardiovasc, AP HP, F-75674 Paris, France Hop Broussais Paris France F-75674 diovasc, AP HP, F-75674 Paris, France
Titolo Testata:
ATHEROSCLEROSIS
fascicolo: 2, volume: 157, anno: 2001,
pagine: 315 - 323
SICI:
0021-9150(200108)157:2<315:AOTRBT>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIGH-DENSITY-LIPOPROTEIN; CHOLESTERYL ESTER TRANSFER; DEPENDENT DIABETES-MELLITUS; TRANSFER PROTEIN-ACTIVITY; CORONARY HEART-DISEASE; APO A-I; RISK FACTOR; CARDIOVASCULAR-DISEASE; PLASMA TRIGLYCERIDE; METABOLIC-CLEARANCE;
Keywords:
hypertriglyceridemia; high density lipoproteins; phospholipid; cholesterol efflux; Fu5AH cells;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: Fournier, N Fac Sci Pharmaceut & Biol Chatenay Malabry, Lab Biochim Appliquee, Chatenay Malabry, France Fac Sci Pharmaceut & Biol Chatenay Malabry Chatenay Malabry France
Citazione:
N. Fournier et al., "Analysis of the relationship between triglyceridemia and HDL-phospholipid concentrations: consequences on the efflux capacity of serum in the Fu5AH system", ATHEROSCLER, 157(2), 2001, pp. 315-323

Abstract

The high triglyceride/low HDL-cholesterol trait is a corm-non finding in the general population. The aim of the present study was to analyze and interpret the relationships between triglycerides (TG), HDL-related parameters and serum cholesterol efflux potential in an asymptomatic population including both normo- and hyperlipidemic individuals. In a large sample (n = 1143) of this population, there was a negative correlation between TG and HDL-cholesterol (HDL-C) (r = -0.49, P < 0.0001) whereas the negative correlationbetween TG and HDL-phospholipid (HDL-PL) (r = -0.29, P < 0.0001) was weaker, leading to a strong positive correlation between TG and HDL-PL/C ratio (r = 0.58, P < 0.0001). Thus, increased TG concentrations were associated with an enrichment of HDL with PL. Since we have demonstrated previously thatHDL-PL is the major determinant for cholesterol efflux potential from Fu5AH rat hepatoma cells, we determined the effect of the variations in HDL lipid composition on the cholesterol efflux capacity in a subsample of 198 subjects. Compared with normolipidemic subjects (NLP) (TG: 1.7 mmol/l; LDL-C:less than or equal to 4.1 mmol/l, n = 58), hypertriglyceridemic subjects (HTG) (TG > 1.7 mmol/l, n = 63) exhibited lower HDL-C levels (1.08 +/- 0.21 vs. 1.25 +/- 0,32, P = 0.0003) whereas they showed similar HDL-PL concentrations (1.25 +/- 0.21 vs. 1.25 +/- 2.7) and, thus, higher HDL-PL/C ratio (1.17+/- 0.15 vs. 1.02 +/- 0.14, P = 0,0001). The relative efflux capacity of serum measured in the Fu5AH system (5% serum, 4 h incubation at 37 degreesC was on average identical in the HTG and NLP groups. Thus, this study provides evidence that despite decreased HDL concentrations, as determined routinely by the HDL-C assay, some HTG subjects maintained serum cholesterol efflux capacity thanks to the enrichment of HDL with PL. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 15:56:16