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Titolo:
Cross-sectional association of soluble thrombomodulin with mild peripheralartery disease; the ARIC study
Autore:
Salomaa, V; Matej, C; Aleksic, N; Sansores-Garcia, L; Folsom, AR; Juneja, H; Park, E; Wu, KK;
Indirizzi:
KTL Natl Publ Hlth Inst, Dept Epidemiol & Hlth Promot, FIN-00300 Helsinki,Finland KTL Natl Publ Hlth Inst Helsinki Finland FIN-00300 0300 Helsinki,Finland Univ Texas, Sch Med, Div Hematol, Houston, TX USA Univ Texas Houston TX USA v Texas, Sch Med, Div Hematol, Houston, TX USA Univ Minnesota, Sch Publ Hlth, Div Epidemiol, Minneapolis, MN USA Univ Minnesota Minneapolis MN USA th, Div Epidemiol, Minneapolis, MN USA Univ N Carolina, Dept Biostat, Collaborat Studies Coordinating Ctr, ChapelHill, NC USA Univ N Carolina Chapel Hill NC USA Coordinating Ctr, ChapelHill, NC USA
Titolo Testata:
ATHEROSCLEROSIS
fascicolo: 2, volume: 157, anno: 2001,
pagine: 309 - 314
SICI:
0021-9150(200108)157:2<309:CAOSTW>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY-HEART-DISEASE; ACTIVABLE FIBRINOLYSIS INHIBITOR; ENDOTHELIAL-CELL MARKERS; CASE-COHORT DESIGN; ATHEROSCLEROSIS RISK; CARDIOVASCULAR-DISEASE; VASCULAR-DISEASE; FACTOR-VIII; P-SELECTIN; THROMBIN;
Keywords:
thrombomodulin; atherosclerosis; peripheral artery disease;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Salomaa, V KTL Natl Publ Hlth Inst, Dept Epidemiol & Hlth Promot, Mannerheimintie 166, FIN-00300 Helsinki, Finland KTL Natl Publ Hlth Inst Mannerheimintie 166 Helsinki Finland FIN-00300
Citazione:
V. Salomaa et al., "Cross-sectional association of soluble thrombomodulin with mild peripheralartery disease; the ARIC study", ATHEROSCLER, 157(2), 2001, pp. 309-314

Abstract

Thrombomodulin, an endothelial membrane glycoprotein, is an essential partof the protein C anti-coagulant pathway. It may also have a role in the regulation of fibrinolysis. We carried out a cross-sectional study to assess the association of soluble thrombomodulin (sTM) with peripheral artery disease (PAD) in a stratified random sample (n = 863) of otherwise healthy black and white participants of the Atherosclerosis Risk in Communities (ARIC) Study. PAD was more common in black than in white participants and associated with classical risk factors in an expected manner; positively with age, smoking, hypertension, diabetes (P = 0.05), and LDL-cholesterol, and inversely with HDL-cholesterol. Significant positive associations were observed also with fibrinogen and white blood cell count. Overall, the sTM concentration was not a significant predictor of PAD. The association was, however, modified by the level of factor VIII:C in whites (P = 0.002 for the interaction), but not in blacks. Protein C was inversely associated with PAD prevalence (odds ratio 0.33, 95% CI 0.18-0.61, P = 0.0004). sTM was inversely associated with plasminogen, but no associations with t-PA, PAI-1, Or D-dimer were seen. In conclusion, the present results provide some additional evidence on the role of thrombomodulin-protein C pathway in atherosclerotic disease and support our earlier observation on interaction between sTM and factor VIII:C. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

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Documento generato il 28/11/20 alle ore 04:12:29