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Titolo:
Environmental mycobacterial diseases in patients with and without HIV infection: epidemiology, clinical features and evolution
Autore:
Martinez-Moragon, E; Menendez, R; Palasi, P; Santos, M; Aldeguer, JL;
Indirizzi:
Hosp Univ La Fe, Serv Neumol, Unidad Enfermedades Infecciosas, Valencia 46009, Spain Hosp Univ La Fe Valencia Spain 46009 Infecciosas, Valencia 46009, Spain Hosp Univ La Fe, Microbiol Serv, Unidad Enfermedades Infecciosas, Valencia46009, Spain Hosp Univ La Fe Valencia Spain 46009 s Infecciosas, Valencia46009, Spain Hosp Sagunto, Unidad Neumol, Valencia, Spain Hosp Sagunto Valencia Spain osp Sagunto, Unidad Neumol, Valencia, Spain
Titolo Testata:
ARCHIVOS DE BRONCONEUMOLOGIA
fascicolo: 6, volume: 37, anno: 2001,
pagine: 281 - 286
SICI:
0300-2896(200106)37:6<281:EMDIPW>2.0.ZU;2-2
Fonte:
ISI
Lingua:
SPA
Soggetto:
AVIUM COMPLEX INFECTION; HUMAN-IMMUNODEFICIENCY-VIRUS; NONTUBERCULOUS MYCOBACTERIA; PULMONARY-DISEASE; AIDS; CLARITHROMYCIN; LUNG; DIAGNOSIS;
Keywords:
non-tuberculous mycobacteria; mycobacterial infection; HIV infection; immunocompetent patients;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Menendez, R Hosp Univ La Fe, Serv Neumol, Unidad Enfermedades Infecciosas,Avda Campanar 21, Valencia 46009, Spain Hosp Univ La Fe Avda Campanar 21 Valencia Spain 46009 , Spain
Citazione:
E. Martinez-Moragon et al., "Environmental mycobacterial diseases in patients with and without HIV infection: epidemiology, clinical features and evolution", ARCH BRONCO, 37(6), 2001, pp. 281-286

Abstract

The objective of the present study was to ascertain the clinical features,risk factors, microbiologic spectrum and course of disease after treatmentof infections by environmental mycobacteria (EM) in patients with and without HIV infection in our community. Eighty-eight patients with diseases caused by EM diagnosed between 1989 and 1997 were studied; 46 (52.7%) were HIV-positive. Mycobacterium kansasii was the most prevalent pathogen (54%) overall, followed by M. avium complex (40%). However, M. avium complex was most prevalent among HIV-positive patients (61%) and M. kansasii was most prevalent among HIV-negative patients (76%). Localized lung infectious were most common among HIV-negative patients, whereas 74% of HIV-positive patients had disseminated disease. Among HIV-negative patients, chronic obstructive pulmonary disease and corticosteroid use were common associations. Pulmonary disease was subacute and non-specific in both patient groups, whereas abdominal pain was the first symptom of most patients with disseminated disease. On the chest films of 76% of the HIV-negative patients, we observed cavitation and infiltrates; 60% of HIV-negative patients had normal x-rays. No differences in antibiotic sensitivity were observed between strains from HIV-positive and HIV-negative patients. The prognosis was good in the HIV-negative group with combined therapy with 2 to 4 first-line antituberculous drugs, whereas response was poor in HIV-positive patients in spite of prolonged treatment with 3 to 5 drugs. Nevertheless, thanks to the highly effective anti-retroviral treatment of recent years, we seem to be observing improved response to therapy with less aggressive forms of EM disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 20:44:14