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Titolo:
Effect of high dietary cholesterol on gentamicin-induced nephrotoxicity inrabbits
Autore:
Abu-Spetan, KA; Abdel-Gayoum, AA;
Indirizzi:
Garyounis Univ, Fac Med, Dept Biochem, Benghazi, Libya Garyounis Univ Benghazi Libya v, Fac Med, Dept Biochem, Benghazi, Libya
Titolo Testata:
ARCHIVES OF TOXICOLOGY
fascicolo: 5, volume: 75, anno: 2001,
pagine: 284 - 290
SICI:
0340-5761(200107)75:5<284:EOHDCO>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
APPROVED RECOMMENDATION 1985; 2-OXOGLUTARATE AMINOTRANSFERASE; CATALYTIC CONCENTRATION; NEPHROTIC SYNDROME; IFCC METHODS; RATS; PLASMA; MECHANISMS; INJURY; SERUM;
Keywords:
high-cholesterol diet; gentamicin nephrotoxicity; rabbit;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Abdel-Gayoum, AA Garyounis Univ, Fac Med, Dept Biochem, Benghazi, Libya Garyounis Univ Benghazi Libya Biochem, Benghazi, Libya
Citazione:
K.A. Abu-Spetan e A.A. Abdel-Gayoum, "Effect of high dietary cholesterol on gentamicin-induced nephrotoxicity inrabbits", ARCH TOXIC, 75(5), 2001, pp. 284-290

Abstract

Administration of gentamicin to rabbits intramuscularly at a dose of 80 mg/kg per day for 5 days induced nephrotoxicity exhibited by significantly (P< 0.001) elevated serum urea and creatinine levels and a significant (P < 0.001) decrease in renal cortical alkaline phosphatase (ALP) activity, in addition to tubular necrosis revealed by the histopathological examination of the kidney cortices. The deranged parameters returned to normal within I week of drug withdrawal, except the cortical ALP activity, which was still significantly lower compared to control. In contrast, feeding of 2% cholesterol-supplemented diet (CSD) to the rabbits for 15 days did not produce anynephrotoxic effects. However, the concurrent feeding of CSD for 15 days and gentamicin treatment at a dose of 80 mg/kg per day for 5 days, starting from day 10 of feeding, resulted in extensive nephrotoxic effects which weremore severe than those observed with the gentamicin alone, with delayed recovery of the injured kidney following drug withdrawal. Gentamicin treatment produced significant elevation in serum total cholesterol, which was greater in animals fed with CSD. The serum triglyceride levels in the groups injected with gentamicin were also significantly greater than their respective controls. However, the serum phosphlipids were significantly reduced withgentamicin treatment and this reduction was greater in animals fed with cholesterol and treated with the drug. The liver cholesterol contents in animals fed with the CSD were significantly higher than those fed with the plain diet. However, the kidney cortices of the animals injected with the gentamicin showed significantly increased total phospholipid contents compared to their respective controls. On the other hand, the liver function was not altered in any of the experimental groups. In summary, the present results suggest that cholesterol feeding exacerbated the gentamicin-induced nephrotoxicity. Moreover, it delayed the period required by the injured kidney to recover back to normal. However, neither gentamicin treatment nor cholesterol feeding, or both together, had any injurious effects on the liver.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 00:59:46