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Titolo:
Cardiac rhythm disturbances and prolongation of the QTc interval with halofantrine
Autore:
Lavallee, I; Marc, E; Moulin, F; Treluyer, JM; Imbert, P; Gendrel, D;
Indirizzi:
Hop St Vincent de Paul, F-75674 Paris 14, France Hop St Vincent de Paul Paris France 14 de Paul, F-75674 Paris 14, France Hop Instruct Armees Begin, St Mande, France Hop Instruct Armees Begin St Mande France rmees Begin, St Mande, France
Titolo Testata:
ARCHIVES DE PEDIATRIE
fascicolo: 8, volume: 8, anno: 2001,
pagine: 795 - 800
SICI:
0929-693X(200108)8:8<795:CRDAPO>2.0.ZU;2-C
Fonte:
ISI
Lingua:
FRE
Soggetto:
UNCOMPLICATED FALCIPARUM-MALARIA; ANTIMALARIAL TREATMENT; CHILDREN;
Keywords:
heart rate; drug effects; halofantrin; malaria, falciparum; drug therapy; child;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Gendrel, D Hop St Vincent de Paul, 47-82 Ave Denfert Rochereau, F-75674 Paris 14, France Hop St Vincent de Paul 47-82 Ave Denfert Rochereau Paris France 14
Citazione:
I. Lavallee et al., "Cardiac rhythm disturbances and prolongation of the QTc interval with halofantrine", ARCH PED, 8(8), 2001, pp. 795-800

Abstract

Objective.-To determine the importance of prolonged QT interval and electrocardiographic changes in children treated with halofantrin for an acute malaria attack. Results.-Out of 25 children treated with halofantrin, nine had an increaseof QTc interval <440 ms and ten a QTc >440 ms on control 24 h after the first dose. A 9-year-old girl, treated with halofantrin, had bradycardia and increase of QTc interval for six days, with a normal halofantrin blood level. Conclusion.-These data show that cardiac monitoring during halofantrin treatment is mandatory in children as in adults. Contraindications of halofantrin treatment must be respected, particularly a long congenital QT interval(C) 2001 Editions scientifiques et medicales Elsevier SAS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 22:23:14