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Titolo:
Influence of virus strain, challenge dose, and time of therapy initiation on the in vivo influenza inhibitory effects of RWJ-270201
Autore:
Sidwell, RW; Smee, DF; Huffman, JH; Barnard, DL; Morrey, JD; Bailey, KW; Feng, WC; Babu, YS; Bush, K;
Indirizzi:
Utah State Univ, Inst Antiviral Res, Logan, UT 84322 USA Utah State Univ Logan UT USA 84322 nst Antiviral Res, Logan, UT 84322 USA BioCryst Pharmaceut Inc, Birmingham, AL 35244 USA BioCryst Pharmaceut IncBirmingham AL USA 35244 Birmingham, AL 35244 USA RW Johnson Pharmaceut Res Inst, Raritan, NJ 08809 USA RW Johnson Pharmaceut Res Inst Raritan NJ USA 08809 Raritan, NJ 08809 USA
Titolo Testata:
ANTIVIRAL RESEARCH
fascicolo: 3, volume: 51, anno: 2001,
pagine: 179 - 187
SICI:
0166-3542(200109)51:3<179:IOVSCD>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEURAMINIDASE INHIBITOR; MICE;
Keywords:
influenza virus; antiviral; RWJ-270201; neuraminidase inhibitor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
9
Recensione:
Indirizzi per estratti:
Indirizzo: Sidwell, RW Utah State Univ, Inst Antiviral Res, Logan, UT 84322 USA Utah State Univ Logan UT USA 84322 l Res, Logan, UT 84322 USA
Citazione:
R.W. Sidwell et al., "Influence of virus strain, challenge dose, and time of therapy initiation on the in vivo influenza inhibitory effects of RWJ-270201", ANTIVIR RES, 51(3), 2001, pp. 179-187

Abstract

The influenza virus neuraminidase inhibitor RWJ-270201 (cyclopentane carboxylic acid, 3[cis-1-(acetylamino)-2-ethylbutyl]-4[(aminoiminomethyl)amino]-2-hydroxy-[cis, 2S, 3R, 4R]) was significantly inhibitory to an infection in mice induced by influenza A/NWS/33 (H1N1) virus when oral gavage (p.o.) treatment with 10 mg/kg per day was delayed at least 60 h after virus exposure. Treatment was 5 mg/kg twice daily for 5 days. Viral challenge doses of influenza A/Shangdong/09/93 (H3N2) virus ranging from the LD70 to the LD100did not affect the marked antiviral efficacy of 12.5 mg/kg of RWJ-270201 administered p.o. twice daily for 5 days beginning 4 h pre-virus exposure; infection by an approximate 2 LD100 dose (10(8) cell culture infectious doses/ml) was only weakly inhibited by the same treatment as seen by significant increase in mean day to death. Murine infections induced by influenza A/Bayern/57/ 93 (H1N1) and B/Lee/40 viruses were significantly inhibited by 100, 10, and 1 mg/kg per day of RWJ-270201 using the above treatment regimen;influenza A/PR/8/34 (H1N1) virus infections in mice were only moderately inhibited, the antiviral effects using this virus being lessening of arterial oxygen decline, reduced lung consolidation, and inhibition of lung virus titers primarily at the higher dosages. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/08/20 alle ore 23:18:37