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Titolo:
Experimental treatment of vascular graft infection due to Staphylococcus epidermidis by in situ replacement with a rifampin-bonded polyester graft
Autore:
Coggia, M; Goeau-Brissonniere, O; Leflon, V; Nicolas, MH; Pechere, JC;
Indirizzi:
Hop Ambroise Pare, Serv Chirurg Vasc, F-92104 Boulogne, France Hop Ambroise Pare Boulogne France F-92104 Vasc, F-92104 Boulogne, France Hop Ambroise Pare, Microbiol Serv, Boulogne, France Hop Ambroise Pare Boulogne France are, Microbiol Serv, Boulogne, France Univ Geneva, Fac Med, Dept Genet & Microbiol, Geneva, Switzerland Univ Geneva Geneva Switzerland t Genet & Microbiol, Geneva, Switzerland
Titolo Testata:
ANNALS OF VASCULAR SURGERY
fascicolo: 4, volume: 15, anno: 2001,
pagine: 421 - 429
SICI:
0890-5096(200107)15:4<421:ETOVGI>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEALED DACRON GRAFT; PROSTHETIC INFECTION; INSITU REPLACEMENT; BACTERIAL BIOFILMS; RELEASE SYSTEM; AORTIC GRAFTS; ANIMAL-MODEL; FIBRIN GLUE; PREVENTION; POLYTETRAFLUOROETHYLENE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: Goeau-Brissonniere, O Hop Ambroise Pare, Serv Chirurg Vasc, 9 Av Charles Gaulle, F-92104 Boulogne, France Hop Ambroise Pare 9 Av Charles Gaulle Boulogne France F-92104
Citazione:
M. Coggia et al., "Experimental treatment of vascular graft infection due to Staphylococcus epidermidis by in situ replacement with a rifampin-bonded polyester graft", ANN VASC S, 15(4), 2001, pp. 421-429

Abstract

In situ prosthetic graft replacement (ISPGR) of an infected prosthesis raises the risk of recurrent infection in the new graft, especially in cases involving drug-resistant microorganisms. The purpose of this animal study was to evaluate in situ replacement of a vascular graft infected by a highly rifampin-resistant strain of Staphylococcus epidermidis with the use of a rifampin-bonded polyester graft. Antibiotic bonding was obtained by soaking grafts in a high dose of rifampin solution (60 mg/mL). The infrarenal abdominal aorta of 20 dogs was replaced using a polyester prosthesis infected with a highly rifampin-resistant strain of Staphylococcus epidermidis. One week later, the 18 surviving animals were randomized into three groups. GroupI (n = 6) did not undergo reoperation. Group II (n = 6) underwent ISPGR using a rifampin-bonded prosthesis. Group III (n = 6) underwent ISPGR using an untreated prosthesis. All surviving animals were killed 28 days after thefirst procedure. Infectious signs were noted and bacteriological study wascarried out on explanted prostheses and various tissue samples. The findings of this experimental study show that soaking a polyester prosthesis in ahigh-dose rifampin solution can prevent reinfection after in situ replacement of a prosthesis infected by a highly rifampin-resistant Staphylococcus epidermidis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/01/21 alle ore 17:37:21