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Titolo:
Hypertension as a risk factor for cerebral injury during cardiopulmonary bypass - Protein S100B and transcranial Doppler findings
Autore:
Schmidt, M; Scheunert, T; Steinbach, G; Schirmer, U; Marx, T; Freitag, N; Reinelt, H;
Indirizzi:
Univ Ulm, Dept Cardiac Anaesthesia, D-89070 Ulm, Germany Univ Ulm Ulm Germany D-89070 t Cardiac Anaesthesia, D-89070 Ulm, Germany Univ Ulm, Dept Cardiac Surg, D-89070 Ulm, Germany Univ Ulm Ulm Germany D-89070 lm, Dept Cardiac Surg, D-89070 Ulm, Germany Univ Ulm, Dept Clin Chem, D-89070 Ulm, Germany Univ Ulm Ulm Germany D-89070 v Ulm, Dept Clin Chem, D-89070 Ulm, Germany
Titolo Testata:
ANAESTHESIA
fascicolo: 8, volume: 56, anno: 2001,
pagine: 733 - 738
SICI:
0003-2409(200108)56:8<733:HAARFF>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD-FLOW VELOCITY; CARDIAC-SURGERY; ARTERY; COMPLICATIONS; ULTRASOUND; PRESSURE; MARKER; S-100; SERUM; INDEX;
Keywords:
surgery, cardiovascular; complications, neurological; blood pressure, hypertension; brain, blood flow, oxygenation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Schmidt, M Univ Ulm, Dept Cardiac Anaesthesia, D-89070 Ulm, Germany Univ Ulm Ulm Germany D-89070 naesthesia, D-89070 Ulm, Germany
Citazione:
M. Schmidt et al., "Hypertension as a risk factor for cerebral injury during cardiopulmonary bypass - Protein S100B and transcranial Doppler findings", ANAESTHESIA, 56(8), 2001, pp. 733-738

Abstract

We studied 22 patients aged 53-78 years scheduled for cardiac surgery under cardiopulmonary bypass. Blood pressure, cardiac output, transcranial Doppler blood flow velocity, arterial blood gases, body temperature and proteinS100B, as a marker for cerebral integrity, were evaluated in normotensive and hypertensive patients. Pre-operative mean (SD) arterial blood pressure was 93 (11) mmHg in the normotensive group compared with 116 (15) mmHg in the hypertensive group. We found an increase in protein S100B levels in bothgroups. Serum protein S100B concentrations in the hypertensive group were significantly higher than in the normotensive group (p < 0.001). The highest mean (SD) values were 2.04 (0.65) <mu>mol.l(-1) in the normotensive groupand 7.02 (4.55) mu mol.l(-1) in the hypertensive group. These results suggest that cardiopulmonary bypass is associated with a significantly higher rate of cerebral injury in hypertensive patients than in normotensive patients. This may be due to altered autoregulation and insufficient cerebral perfusion. Modifications of cardiopulmonary bypass management for hypertensivepatients might be made to decrease the risk of cerebral injury.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 22:56:12