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Titolo:
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy: Decrease in regional cerebral blood volume in hyperintense subcortical lesions inversely correlates with disability and cognitive performance
Autore:
Bruening, R; Dichgans, M; Berchtenbreiter, C; Yousry, T; Seelos, KC; Wu, RH; Mayer, M; Brix, G; Reiser, M;
Indirizzi:
Univ Munich, Inst Clin Radiol, Dept Neuroradiol, Munich, Germany Univ Munich Munich Germany in Radiol, Dept Neuroradiol, Munich, Germany Univ Munich, Dept Neurol, D-8000 Munich, Germany Univ Munich Munich Germany D-8000 h, Dept Neurol, D-8000 Munich, Germany Univ Virginia, Hlth Sci Ctr, Dept Radiol, Charlottesville, VA USA Univ Virginia Charlottesville VA USA ept Radiol, Charlottesville, VA USA Fed Off Radiat Protect, Inst Radiat Hyg, Dept Med Radiat Hyg, Munich, Germany Fed Off Radiat Protect Munich Germany t Med Radiat Hyg, Munich, Germany
Titolo Testata:
AMERICAN JOURNAL OF NEURORADIOLOGY
fascicolo: 7, volume: 22, anno: 2001,
pagine: 1268 - 1274
SICI:
0195-6108(200108)22:7<1268:CADAWS>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
NOTCH3 MUTATIONS; SKIN BIOPSIES; MR-FINDINGS; CADASIL; CONTRAST; STROKE; DEMENTIA; DIFFUSION; BRAIN; LEUKOARAIOSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Bruening, R Univ Munich, Klinikum Grosshadern, Inst Clin Radiol, Marchioninistr 15, D-81377 Munich, Germany Univ Munich Marchioninistr 15 Munich Germany D-81377 Germany
Citazione:
R. Bruening et al., "Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy: Decrease in regional cerebral blood volume in hyperintense subcortical lesions inversely correlates with disability and cognitive performance", AM J NEUROR, 22(7), 2001, pp. 1268-1274

Abstract

BACKGROUND AND PURPOSE: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an arteriopathic syndrome related to a genetic defect on chromosome 19. Characteristic changes in CADASIL can be observed on T2-weighted MR images in the subcortical whitematter. The purpose of this study was to measure changes of regional cerebral blood volume (rCBV) with dynamic contrast-enhanced MR imaging and to correlate the changes to disability and cognitive performance. METHODS: We obtained rCBV measurements of 24 individuals with proven CADASIL on a 1.5-T MR imaging unit. A susceptibility-weighted MR imaging sequence was used for bolus tracking. Principles of the indicator dilution theory were applied to estimate values of absolute rCBV (mL/100 g). Disability wasdetermined by using the Rankin scale, and overall cognitive performance was assessed by using the Mini-Mental State Examination. RESULTS: The mean rCBV in the subcortical white matter that was hyperintense on the T2-weighted images (2.7 +/- 0.8 mL/100 g) was significantly lowerthan the rCBV in the white matter that appeared normal on the T2-weighted images (4.4 +/- 1.3 mL/100 g) (P < .05). The mean rCBV in the gray matter was within the normal range (8.3 +/- 1.7 mL/100 g). Both cognitive impairment and disability negatively correlated with rCBV in the subcortical white matter that was hyperintense (P < .05) but not with rCBV in the normal appearing white matter. rCBV did not correlate with age. CONCLUSION. rCBV measured in the hyperintense subcortical white matter in individuals with CADASIL was decreased and inversely correlated with disability and cognitive impairment.

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Documento generato il 25/09/20 alle ore 00:19:32