Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Induction and maintenance of ethanol self-administration in cynomolgus monkeys (Macaca fascicularis): Long-term characterization of sex and individual differences
Autore:
Vivian, JA; Green, HL; Young, JE; Majerksy, LS; Thomas, BW; Shively, CA; Tobin, JR; Nader, MA; Grant, KA;
Indirizzi:
Wake Forest Univ, Sch Med, Dept Physiol & Pharmacol, Winston Salem, NC 27157 USA Wake Forest Univ Winston Salem NC USA 27157 , Winston Salem, NC 27157 USA Wake Forest Univ, Sch Med, Ctr Neurobehav Study Alcohol, Winston Salem, NC27157 USA Wake Forest Univ Winston Salem NC USA 27157 l, Winston Salem, NC27157 USA Wake Forest Univ, Sch Med, Dept Pathol, Winston Salem, NC 27157 USA Wake Forest Univ Winston Salem NC USA 27157 , Winston Salem, NC 27157 USA Wake Forest Univ, Sch Med, Dept Anesthesiol, Winston Salem, NC 27157 USA Wake Forest Univ Winston Salem NC USA 27157 , Winston Salem, NC 27157 USA
Titolo Testata:
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
fascicolo: 8, volume: 25, anno: 2001,
pagine: 1087 - 1097
SICI:
0145-6008(200108)25:8<1087:IAMOES>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXCESSIVE ALCOHOL-CONSUMPTION; RHESUS-MONKEYS; ORAL ETHANOL; DRINKING PATTERNS; NONHUMAN-PRIMATES; SOCIAL-GROUPS; RATS;
Keywords:
alcohol; ethanol; individual differences; self-administration; sex differences;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Grant, KA Wake Forest Univ, Sch Med, Dept Physiol & Pharmacol, Med Ctr Blvd, WinstonSalem, NC 27157 USA Wake Forest Univ Med Ctr Blvd Winston Salem NC USA 27157 157 USA
Citazione:
J.A. Vivian et al., "Induction and maintenance of ethanol self-administration in cynomolgus monkeys (Macaca fascicularis): Long-term characterization of sex and individual differences", ALC CLIN EX, 25(8), 2001, pp. 1087-1097

Abstract

Background: Investigations of oral ethanol self-administration in nonhumanprimates have revealed important parallels with human alcohol use and abuse, yet many fundamental questions concerning the individual risk to, and the biological basis of, excessive ethanol consumption remain unanswered. Moreover, many conditions of access to ethanol in nonhuman primate research are largely unexplored. This set of experiments extends within- and across-session exposure to ethanol to more fully characterize individual differencesin oral ethanol self-administration. Methods: Eight male and eight female adult cynomolgus monkeys (Macaca fascicularis) were exposed to daily oral ethanol self-administration sessions for approximately 9 months. During the first 3 months, a fixed-time (IT) schedule of food delivery was used to induce the consumption of an allotted dose of ethanol in 16-hr sessions. Subsequently, the FT schedule was suspended, and ethanol was available ad libitum for 6 months in 16- or 22-hr sessions. Results: Cynomolgus monkeys varied greatly in their propensity to self-administer ethanol, with sex and individual differences apparent within 10 days of ethanol exposure. Over the last 3 months of ethanol access, individualaverage ethanol intakes ranged from 0.6 to 4.0 g/kg/day, resulting in blood ethanol concentrations from 5 to 235 mg/dl. Males drank approximately 1.5-fold more than females. In addition, heavy-, moderate-, and light-drinkingphenotypes were identified by using daily ethanol intake and the percentage of daily calories obtained from ethanol as criteria. Conclusions: Cynomolgus monkeys displayed a wide intersubject range of oral ethanol self-administration with a procedure that used a uniform and prolonged induction that restricted early exposure to ethanol and subsequently allowed unlimited access to ethanol. There were sex and stable individual differences in the propensity of monkeys to consume ethanol, indicating thatthis species will be important in characterizing risk factors associated with heavy-drinking phenotypes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 19:32:36