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Titolo:
Synthesis of Hexahydro-1H-1,4-diazepine analogues carrying the segment of (1-arylacetamide-2-tertiaryamide) ethane (II)
Autore:
Shen, JS; Lei, LJ; Yan, TM; Wei, M; Ji, RY;
Indirizzi:
Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China Chinese Acad Sci Shanghai Peoples R China 200031 200031, Peoples R China
Titolo Testata:
ACTA CHIMICA SINICA
fascicolo: 8, volume: 59, anno: 2001,
pagine: 1317 - 1322
SICI:
0567-7351(2001)59:8<1317:SOHACT>2.0.ZU;2-H
Fonte:
ISI
Lingua:
CHI
Soggetto:
RECEPTOR; POTENT; AGONISTS;
Keywords:
selective kappa receptor agonists; hexahydro-1H-1,4-diazepine analogues; (1-arylacetamide-2-tertiaryamide) ethane structure;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
12
Recensione:
Indirizzi per estratti:
Indirizzo: Shen, JS Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, PeoplesR China Chinese Acad Sci Shanghai Peoples R China 200031 eoples R China
Citazione:
J.S. Shen et al., "Synthesis of Hexahydro-1H-1,4-diazepine analogues carrying the segment of (1-arylacetamide-2-tertiaryamide) ethane (II)", ACT CHIM S, 59(8), 2001, pp. 1317-1322

Abstract

2-(1-(4-(N-phenyl-N- propionyl) amino) piperidyl)-hexahydro-1H-1,4-diazepine 7 was prepared starting from 3 through reduction, chlorination, amine substitution, and debenzylation. Seven target compounds of hexahydro-1H-1,4-diazepine analogues carrying the segment of (1- arylacetamide-2-tertiaryamide) ethane were synthesized through selective acylation and acylation of compound 7, and the four target compounds 10a similar to 10d containing hydrophilic group of hydroxy were achieved through debenzylation of 9a, 9b, 9c and 9d. These products were characterized by IR, EIMS, elementary analysis and H-1 NMR. Compounds of 9a similar to 9g and 10a similar to 10d were testedfor their biological activities.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 09:52:11