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Titolo:
Extended joint resurfacing of the knee with autologous chondrocyte-collagen transplantation. A report on the first patient in Austria
Autore:
Marlovits, S; Pajenda, G; Trattnig, S; Vecsei, V;
Indirizzi:
Allgemeines Krankenhaus Wien, Univ Klin Unfallchirurg, A-1090 Vienna, Austria Allgemeines Krankenhaus Wien Vienna Austria A-1090 -1090 Vienna, Austria Ludwig Boltzmann Inst Biomech & Zellbiol, Vienna, Austria Ludwig BoltzmannInst Biomech & Zellbiol Vienna Austria Vienna, Austria Allgemeines Krankenhaus Wien, Univ Klin Radiol, Vienna, Austria Allgemeines Krankenhaus Wien Vienna Austria lin Radiol, Vienna, Austria
Titolo Testata:
WIENER KLINISCHE WOCHENSCHRIFT
fascicolo: 13-14, volume: 113, anno: 2001,
pagine: 531 - 539
SICI:
0043-5325(20010716)113:13-14<531:EJROTK>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
GER
Keywords:
cartilage; cartilage defect; cartilage repair; autologous transplantation; tissue engineering;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Marlovits, S Allgemeines Krankenhaus Wien, Univ Klin Unfallchirurg, Wahringer Gurtel 18-20, A-1090 Vienna, Austria Allgemeines Krankenhaus Wien Wahringer Gurtel 18-20 Vienna Austria A-1090
Citazione:
S. Marlovits et al., "Extended joint resurfacing of the knee with autologous chondrocyte-collagen transplantation. A report on the first patient in Austria", WIEN KLIN W, 113(13-14), 2001, pp. 531-539

Abstract

Articular cartilage has a limited capacity for repair. Repair tissue similar to articular cartilage can be induced by filling articular defects with tissues and cells capable of chondrogenesis. For the biological resurfacingof joints, biocompatible carriers can be used in combination with culturedcells and methods for tissue engineering. An autologous, in vitro designed joint transplant was used for the therapyof an extended full-thickness posttraumatic and post-infectious cartilage defect in the patellofemoral joint of a young patient. A cartilage biopsy was taken during an arthroscopy and chondrocytes were isolated and cultivated. After reaching a sufficient cell number in cell culture, the chondrocytes were combined with a collagen membrane. Implantation of the three-dimensional cell-collagen membrane was performed during a second operation, involving arthrotomy of the joint and resection of the destroyed cartilage surface. After the follow-up of 6 months all used scores for the measurement of theknee function improved, mainly due to the reduction of symptomatic pain. Magnetic Resonance Imaging of the transplanted joint area revealed the formation of a thin cartilage layer.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 07:56:16