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Titolo:
Osteoporosis due to androgen deprivation therapy in men with prostate cancer
Autore:
Daniell, HW;
Indirizzi:
Univ Calif Davis, Sch Med, Dept Family Practice, Davis, CA 95616 USA Univ Calif Davis Davis CA USA 95616 Family Practice, Davis, CA 95616 USA
Titolo Testata:
UROLOGY
fascicolo: 2A, volume: 58, anno: 2001, supplemento:, S
pagine: 101 - 106
SICI:
0090-4295(200108)58:2A<101:ODTADT>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
BONE-MINERAL DENSITY; TESTICULAR ATROPHY; PHYSICAL-ACTIVITY; WORSE PROGNOSIS; ORCHIECTOMY; CARCINOMA; FRACTURES; OLDER; HYDROCHLOROTHIAZIDE; TURNOVER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Daniell, HW 2626 Edith Ave, Redding, CA 96001 USA 2626 Edith Ave Redding CA USA 96001 ve, Redding, CA 96001 USA
Citazione:
H.W. Daniell, "Osteoporosis due to androgen deprivation therapy in men with prostate cancer", UROLOGY, 58(2A), 2001, pp. 101-106

Abstract

Objectives. The frequency of osteoporotic fractures is greatly increased in men receiving androgen deprivation therapy (ADT), but whether the risk ofosteoporosis differs between different types of ADT or between continuous and intermittent therapy has not been determined. Techniques for modifying ADT-associated bone loss have not been clearly identified. Methods. Risk factors for the development of osteoporosis in men receivingADT will be reviewed. Relations between bone mineral density (BMD) values and the development of osteoporotic fractures, along with methods for preventing both BMD loss and osteoporotic fractures, will be discussed. Results. ADT rapidly accelerates bone loss among men with prostate cancer and multiplies the risk of osteoporotic fractures among them. Factors otherthan ADT-associated bone loss contributing to this fracture risk include both decreased BMD before ADT and an increased tendency to fall associated with muscle weakness, impaired balance, and postural hypotension. Each of these factors may be associated with poor nutrition, advancing malignant disease, hypogonadism of non-ADT origin, advanced age, and the use of narcotic,anti hypertensive, or sedative medications. Although the success of therapy designed to improve BMD values and lower the fracture rate in these patients has not been explored, regular exercise, smoking abstinence, adequate calcium, protein, and vitamin D intake, maintenance of weight, and the use of bisphosphonates or calcitonin may each have a useful therapeutic role. Theoretical considerations suggest that intermittent ADT may decrease the frequency of ADT-associated osteoporosis. Conclusions. An urgent need exists for the definition of techniques usefulin preventing osteoporotic fractures in men receiving ADT for prostate cancer. (C) 2001, Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 09:27:59