Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Post-translational protein modifications in antigen recognition and autoimmunity
Autore:
Doyle, HA; Mamula, MJ;
Indirizzi:
Yale Univ, Sch Med, Rheumatol Sect, New Haven, CT 06520 USA Yale Univ NewHaven CT USA 06520 Rheumatol Sect, New Haven, CT 06520 USA
Titolo Testata:
TRENDS IN IMMUNOLOGY
fascicolo: 8, volume: 22, anno: 2001,
pagine: 443 - 449
SICI:
1471-4906(200108)22:8<443:PPMIAR>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYSTEMIC-LUPUS-ERYTHEMATOSUS; T-CELL RECOGNITION; MYELIN BASIC-PROTEIN; IN-VITRO; POSTTRANSLATIONAL MODIFICATION; CYSTEINE RESIDUES; INDUCED APOPTOSIS; MOLECULAR-BASIS; SELF-PROTEINS; II COLLAGEN;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
61
Recensione:
Indirizzi per estratti:
Indirizzo: Mamula, MJ Yale Univ, Sch Med, Rheumatol Sect, 333 Cedar St,LCI 609,POB 208031, New Haven, CT 06520 USA Yale Univ 333 Cedar St,LCI 609,POB 208031 NewHaven CT USA 06520
Citazione:
H.A. Doyle e M.J. Mamula, "Post-translational protein modifications in antigen recognition and autoimmunity", TRENDS IMMU, 22(8), 2001, pp. 443-449

Abstract

It is estimated that 50-90% of the proteins in the human body are posttranslationally modified. In the proper context, these modifications are necessary for the biological functions of a vast array of proteins and the effector functions of the cells in which they reside. However, it is now clear that some post-translational modifications can create new self antigens (Ags)or even mask Ags normally recognized by the immune system. In either case,they profoundly affect the recognition of Ag by bone marrow-derived cells, as well as their effector functions. How do post-translational protein modifications affect the processing of foreign and self Ags and what is their role in the origin of autoimmune responses?

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 14:23:10