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Titolo:
Antinuclear autoantibodies as potential antineoplastic agents
Autore:
Torchilin, VP; Iakoubov, LZ; Estrov, Z;
Indirizzi:
Northeastern Univ, Bouve Coll Hlth Sci, Dept Pharmaceut Sci, Boston, MA 02115 USA Northeastern Univ Boston MA USA 02115 harmaceut Sci, Boston, MA 02115 USA Procyon Biopharma Inc, Dorval, PQ H9P 1H7, Canada Procyon Biopharma Inc Dorval PQ Canada H9P 1H7 Dorval, PQ H9P 1H7, Canada Univ Texas, MD Anderson Canc Ctr, Dept Bioimmunotherapy, Houston, TX 77030USA Univ Texas Houston TX USA 77030 pt Bioimmunotherapy, Houston, TX 77030USA
Titolo Testata:
TRENDS IN IMMUNOLOGY
fascicolo: 8, volume: 22, anno: 2001,
pagine: 424 - 427
SICI:
1471-4906(200108)22:8<424:AAAPAA>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
MINIMAL RESIDUAL DISEASE; CELL-SURFACE; MULTIPLE-SCLEROSIS; NUCLEOSOMES; ANTIBODIES; CANCER; LEUKEMIA; THERAPY; DNA; TUMORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Torchilin, VP Northeastern Univ, Bouve Coll Hlth Sci, Dept Pharmaceut Sci,360 Huntington Ave, Boston, MA 02115 USA Northeastern Univ 360 Huntington Ave Boston MA USA 02115 USA
Citazione:
V.P. Torchilin et al., "Antinuclear autoantibodies as potential antineoplastic agents", TRENDS IMMU, 22(8), 2001, pp. 424-427

Abstract

The immune system confines neoplasia at various stages of tumor development. Whereas the role of cellular immunity has been investigated widely and utilized in the clinic. the importance of humoral immunity in this process has begun to emerge only in recent years. Circulating antinuclear autoantibodies (ANAs) typically found in autoimmune conditions, have also been detected in cancer patients and in healthy elderly individuals. The pathogenic role of ANAs in autoimmunity is well studied; however, little research has been carded out to elucidate the functions of ANAs in cancer patients. Experimental data favoring the antitumor activity of ANAs might support the clinical testing of monoclonal ANAs as a cancer therapy, if confirmed by furtherexperiments.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 16:23:55