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Titolo:
Lymphocyte-mediated immunosurveillance of epithelial cancers?
Autore:
Smyth, MJ; Trapani, JA;
Titolo Testata:
TRENDS IN IMMUNOLOGY
fascicolo: 8, volume: 22, anno: 2001,
pagine: 409 - 411
SICI:
1471-4906(200108)22:8<409:LIOEC>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONGENIC NORMAL MICE; TUMOR SURVEILLANCE; IMMUNOCOMPETENT MICE; PEPTIDE TRANSPORTER; IMMUNE RECOGNITION; NUDE-MICE; SARCOMAS; MELANOMA; ANTIGEN; CELLS;
Tipo documento:
Editorial Material
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
M.J. Smyth e J.A. Trapani, "Lymphocyte-mediated immunosurveillance of epithelial cancers?", TRENDS IMMU, 22(8), 2001, pp. 409-411

Abstract

The validity and importance of the immunosurveillance of tumors have been debated ever since Burnet and Thomas outlined several key concepts that underpin our understanding of tumor immunity. With the development of gene-targeting technology, it has been shown that interferon gamma (IFN-gamma) and perforin - key effector molecules of both the innate and adaptive immune systems - contribute to the prevention of of tumors in mice. These findings have rejuvenated interest in the immunosurveillance of tumors, and recent data have provided evidence that the immune system influences the developmentof some spontaneous epithelial malignancies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 13:26:43