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Titolo:
Immunomodulation induced by Avene spring water on Th1-and Th2-dependent cytokine production in healthy subjects and atopic dermatitis patients
Autore:
Portales, P; Aries, MF; Licu, D; Pinton, J; Hernandez-Pion, C; Gall, Y; Dupuy, P; Charveron, M; Clot, J;
Indirizzi:
Hop St Eloi, Immunol Lab, F-34295 Montpellier 5, France Hop St Eloi Montpellier France 5 unol Lab, F-34295 Montpellier 5, France Avene Med Spa Ctr, Avene, France Avene Med Spa Ctr Avene FranceAvene Med Spa Ctr, Avene, France Fac Med Rangueil, Lab Biol Cellulaire Cutanee, Inst Rech Pierre Fabre, Toulouse, France Fac Med Rangueil Toulouse France st Rech Pierre Fabre, Toulouse, France
Titolo Testata:
SKIN PHARMACOLOGY AND APPLIED SKIN PHYSIOLOGY
fascicolo: 4, volume: 14, anno: 2001,
pagine: 234 - 242
SICI:
1422-2868(200107/08)14:4<234:IIBASW>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTERFERON-GAMMA; IGE PRODUCTION; IFN-GAMMA; CELL; INTERLEUKIN-4; PATHOGENESIS; EXPRESSION; ACTIVATION; PATTERNS; ANTIGEN;
Keywords:
Avene spring water; immunomodulation; Th1; Th2; cytokine; atopic dermatitis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Clot, J Hop St Eloi, Immunol Lab, F-34295 Montpellier 5, France Hop St Eloi Montpellier France 5 , F-34295 Montpellier 5, France
Citazione:
P. Portales et al., "Immunomodulation induced by Avene spring water on Th1-and Th2-dependent cytokine production in healthy subjects and atopic dermatitis patients", SKIN PH APP, 14(4), 2001, pp. 234-242

Abstract

Avene spring water (ASW) is commonly used in France for treating atopic dermatitis and psoriasis. Previous works demonstrated modulation of cell membrane fluidity by ASW. The aims of the present study were (a) to investigatea possible in vitro effect of ASW on Th1- and Th2-dependent cytokine production using peripheral blood mononuclear cells from healthy individuals and(b) to investigate both the in vitro effect of ASW on AD patients' cells and the in vivo cellular and clinical modifications induced by a 3-week Avene Medical Spa water cure (AMSWC). The effect of ASW was tested on lymphocyte cultures, which were stimulated in vitro by various mitogens and a superantigen of staphylococcal origin. The lymphocyte proliferation and the production of the cytokines IL-2, IL-4 and IFN-gamma were tested. The results showed that ASW-containing medium enhanced the lymphoproliferative response to some mitogens. IL-2 and IFN-gamma production were also increased in stimulated culture supernatants. Conversely, ASW-containing medium induced a decrease in IL-4 production by normal peripheral blood lymphocytes. Furthermore, AMSWC was able to amend the clinical features as well as the immunological Th2 profile of atopic dermatitis. Copyright (C) 2001 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 09:49:24