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Titolo:
Immunocyte Ca2+ influx system mediated by LTRPC2
Autore:
Sano, Y; Inamura, K; Miyake, A; Mochizuki, S; Yokoi, H; Matsushime, H; Furuichi, K;
Indirizzi:
Yamanouchi Pharmaceut Co Ltd, Inst Drug Discovery Res, Mol Med Labs, Tsukuba, Ibaraki 3058585, Japan Yamanouchi Pharmaceut Co Ltd Tsukuba Ibaraki Japan 3058585 3058585, Japan
Titolo Testata:
SCIENCE
fascicolo: 5533, volume: 293, anno: 2001,
pagine: 1327 - 1330
SICI:
0036-8075(20010817)293:5533<1327:ICISMB>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYCLIC ADP-RIBOSE; CHANNELS; TRP; DROSOPHILA; RECEPTOR; PROTEIN; GENE; PHOTOTRANSDUCTION; LYMPHOCYTES; FAMILY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Sano, Y Yamanouchi Pharmaceut Co Ltd, Inst Drug Discovery Res, Mol Med Labs, 21 Miyukigaoka, Tsukuba, Ibaraki 3058585, Japan Yamanouchi Pharmaceut CoLtd 21 Miyukigaoka Tsukuba Ibaraki Japan 3058585
Citazione:
Y. Sano et al., "Immunocyte Ca2+ influx system mediated by LTRPC2", SCIENCE, 293(5533), 2001, pp. 1327-1330

Abstract

We characterized an activation mechanism of the human LTRPC2 protein, a member of the transient receptor potential family of ion channels, and demonstrated that LTRPC2 mediates Call influx into immunocytes. Intracellular pyrimidine nucleotides, adenosine 5'-diphosphoribose (ADPR), and nicotinamide adenine dinucleotide (NAD), directly activated LTRPC2, which functioned as a Ca2+-permeable nonselective cation channel and enabled Ca2+ influx into cells. This activation was suppressed by intracellular adenosine triphosphate. These results reveal that ADPR and NAD act as intracellular messengers and may have an important role in Ca2+ influx by activating LTRPC2 in immunocytes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 17:49:20