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Titolo:
Skeletal muscle dysfunction in chronic obstructive pulmonary disease
Autore:
Mador, MJ; Bozkanat, E;
Indirizzi:
SUNY Buffalo, Vet Adm Med Ctr, Div Pulm Crit Care & Sleep Med, Sect 111S, Buffalo, NY 14215 USA SUNY Buffalo Buffalo NY USA 14215 p Med, Sect 111S, Buffalo, NY 14215 USA GATA Camlica Hosp Chest Dis, Istanbul, Turkey GATA Camlica Hosp Chest DisIstanbul Turkey Chest Dis, Istanbul, Turkey
Titolo Testata:
RESPIRATORY RESEARCH
fascicolo: 4, volume: 2, anno: 2001,
pagine: 216 - 224
SICI:
1465-993X(2001)2:4<216:SMDICO>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASTUS LATERALIS MUSCLE; RANDOMIZED CONTROLLED TRIAL; CHRONIC RESPIRATORY-FAILURE; HORMONE-DEFICIENT ADULTS; GROWTH-HORMONE; FIBER TYPES; MAGNETIC-RESONANCE; COPD PATIENTS; LUNG-DISEASE; TESTOSTERONE REPLACEMENT;
Keywords:
exercise; lung diseases; muscle; nutrition disorder; obstructive; rehabilitation; skeletal;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
88
Recensione:
Indirizzi per estratti:
Indirizzo: Mador, MJ SUNY Buffalo, Vet Adm Med Ctr, Div Pulm Crit Care & Sleep Med, Sect 111S, 3495 Bailey Ave, Buffalo, NY 14215 USA SUNY Buffalo 3495 Bailey Ave Buffalo NY USA 14215 , NY 14215 USA
Citazione:
M.J. Mador e E. Bozkanat, "Skeletal muscle dysfunction in chronic obstructive pulmonary disease", RESPIR RES, 2(4), 2001, pp. 216-224

Abstract

It has become increasingly recognized that skeletal muscle dysfunction is common in patients with chronic obstructive pulmonary disease (COPD). Muscle strength and endurance are decreased, whereas muscle fatigability is increased. There is a reduced proportion of type I fibers and an increase in type II fibers. Muscle atrophy occurs with a reduction in fiber cross-sectional area. Oxidative enzyme activity is decreased, and measurement of muscle bioenergetics during exercise reveals a reduced aerobic capacity. Deconditioning is probably very important mechanistically. Other mechanisms that maybe of varying importance in individual patients include chronic hypercapnia and/or hypoxia, nutritional depletion, steroid usage, and oxidative stress. Potential therapies include exercise training, oxygen supplementation, nutritional repletion, and administration of anabolic hormones.

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Documento generato il 19/01/20 alle ore 15:09:55