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Titolo:
Reduction of long-term effects of local heating of the testis by treatmentof rats with a GnRH agonist and an anti-androgen
Autore:
Setchell, BP; Ploen, L; Ritzen, EM;
Indirizzi:
Karolinska Hosp, Pediat Endocrinol Unit, S-10401 Stockholm, Sweden Karolinska Hosp Stockholm Sweden S-10401 Unit, S-10401 Stockholm, Sweden Swedish Univ Agr Sci, Fac Vet Med, Dept Anat & Histol, S-75007 Uppsala, Sweden Swedish Univ Agr Sci Uppsala Sweden S-75007 tol, S-75007 Uppsala, Sweden
Titolo Testata:
REPRODUCTION
fascicolo: 2, volume: 122, anno: 2001,
pagine: 255 - 263
SICI:
1470-1626(200108)122:2<255:ROLEOL>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
TESTICULAR INTERSTITIAL FLUID; PUSH-PULL CANNULA; ADULT-RATS; SPERMATOGONIAL DIFFERENTIATION; SEMINIFEROUS TUBULES; HORMONE AGONIST; IRRADIATED RATS; GONADOTROPIN; SPERMATOGENESIS; TESTOSTERONE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Setchell, BP Univ Adelaide, Dept Anat Sci, Adelaide, SA 5005, Australia Univ Adelaide Adelaide SA Australia 5005 SA 5005, Australia
Citazione:
B.P. Setchell et al., "Reduction of long-term effects of local heating of the testis by treatmentof rats with a GnRH agonist and an anti-androgen", REPRODUCT, 122(2), 2001, pp. 255-263

Abstract

Heating the testes of anaesthetized adult rats to 43 degreesC for 30 min in a waterbath was followed by a large decrease in testis and epididymis mass and number of spermatozoa 35 days later. These parameters had recovered to some extent, but not completely, by days 70 and 97 after heating, but haddecreased again in rats examined on day 182. There were no consistent effects of heating on androgen status, as determined by the concentrations of testosterone in blood and testis fluids, or by seminal vesicle mass, and interstitial fluid volume was increased in the heated testes. Treatment of rats with an implant of a GnRH agonist and daily injections of an anti-androgen for 14 days (sufficient in itself to cause large temporary decreases in tissue mass, number of spermatozoa and androgen status) did not reduce the initial decrease in testis mass or number of spermatozoa seen after heating,but reduced the later decreases in mass and number of spermatozoa significantly. These findings indicate that, as well as causing damage to spermatocytes and spermatids, as previously reported, heating also reduces the ability of spermatogonia to repopulate the seminiferous tubules at longer intervals after heating. Furthermore, it appears that this effect on the spermatogonia can be reduced by treating the animals with a GnRH agonist and anti-androgen, a treatment similar to that shown by other authors to improve recovery of the testis from irradiation or drug treatment.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 21:32:24