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Titolo:
Intraovarian actions of oestrogen
Autore:
Rosenfeld, CS; Wagner, JS; Roberts, RM; Lubahn, DB;
Indirizzi:
Univ Missouri, Dept Anim Sci, Columbia, MO 65211 USA Univ Missouri Columbia MO USA 65211 Dept Anim Sci, Columbia, MO 65211 USA Univ Missouri, Program Mol Biol, Columbia, MO 65211 USA Univ Missouri Columbia MO USA 65211 gram Mol Biol, Columbia, MO 65211 USA Univ Missouri, Dept Biochem, Columbia, MO 65211 USA Univ Missouri Columbia MO USA 65211 Dept Biochem, Columbia, MO 65211 USA Univ Missouri, Dept Vet Pathobiol, Columbia, MO 65211 USA Univ Missouri Columbia MO USA 65211 Vet Pathobiol, Columbia, MO 65211 USA Univ Missouri, Dept Child Hlth, Columbia, MO 65211 USA Univ Missouri Columbia MO USA 65211 pt Child Hlth, Columbia, MO 65211 USA
Titolo Testata:
REPRODUCTION
fascicolo: 2, volume: 122, anno: 2001,
pagine: 215 - 226
SICI:
1470-1626(200108)122:2<215:IAOO>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
ESTROGEN-RECEPTOR-BETA; FOLLICLE-STIMULATING-HORMONE; MESSENGER-RIBONUCLEIC-ACID; RAT GRANULOSA-CELLS; ALPHA ER-ALPHA; OVARIAN FOLLICLE; CORPUS-LUTEUM; IMMUNOHISTOCHEMICAL LOCALIZATION; DIFFERENTIAL EXPRESSION; TARGETED DISRUPTION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
114
Recensione:
Indirizzi per estratti:
Indirizzo: Rosenfeld, CS Univ Missouri, Dept Anim Sci, Columbia, MO 65211 USA Univ Missouri Columbia MO USA 65211 Columbia, MO 65211 USA
Citazione:
C.S. Rosenfeld et al., "Intraovarian actions of oestrogen", REPRODUCT, 122(2), 2001, pp. 215-226

Abstract

Oestrogen regulates several hypothalamic and pituitary hormones, which in turn control ovarian functions. Oestrogen and its metabolites, such as catecholoestrogens, also have direct effects within the ovary. This review examines the roles of oestrogen in regulating ovarian folliculogenesis, ovulation and corpus luteum formation. Oestrogen promotes follicular development, which culminates in ovulation, by potentiating follicular development, granulosa cell expression of gonadotrophin receptors, steroidogenesis, and gap junction formation by granulosa cells, and by inhibiting granulosa cell apoptosis. In addition, oestrogen may be needed for corpus luteum formation and maintenance. Studies on mutant mice that either lack one or both of the known oestrogen receptors or are unable to synthesize oestrogen support somebut not all of these prior inferences of the roles of oestrogen within theovary. Although these transgenic mice have proved useful in determining some of the intraovarian actions of oestrogen, they present confounding problems, including hormonal imbalances, that hinder interpretation. Transgenic mice with conditional or tissue-directed mutations in their oestrogen receptors are needed to dissect the ovarian actions of oestrogen further. In addition, microarray technologies, combined with specific hormone treatment regimens are likely to provide an attractive, alternative approach to using mutant mice in clarifying the direct actions of oestrogen in the ovaries of other species.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/01/21 alle ore 21:43:16