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Titolo:
Startle response during smoking and 24 h after withdrawal predicts successful smoking cessation
Autore:
Postma, P; Kumari, V; Sharma, T; Hines, M; Gray, JA;
Indirizzi:
Inst Psychiat, Dept Psychol, London SE5 8AF, England Inst Psychiat London England SE5 8AF pt Psychol, London SE5 8AF, England City Univ London, Dept Psychol, London EC1V 0HB, England City Univ LondonLondon England EC1V 0HB ychol, London EC1V 0HB, England Inst Psychiat, Div Psychol Med, Sect Cognit Psychopharmacol, London SE5 8AF, England Inst Psychiat London England SE5 8AF opharmacol, London SE5 8AF, England
Titolo Testata:
PSYCHOPHARMACOLOGY
fascicolo: 2-3, volume: 156, anno: 2001,
pagine: 360 - 367
Fonte:
ISI
Lingua:
ENG
Soggetto:
PREPULSE INHIBITION; ANIMAL-MODEL; COGNITIVE PERFORMANCE; NICOTINE DEPENDENCE; TOBACCO WITHDRAWAL; CIGARETTE-SMOKING; BLINK REFLEX; SCHIZOPHRENIA; ATTENTION; SYMPTOMS;
Keywords:
acoustic startle response; prepulse inhibition; nicotine; smoking cessation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Postma, P Inst Psychiat, Dept Psychol, De Crespigny Pk, London SE5 8AF, England Inst Psychiat De Crespigny Pk London England SE5 8AF F, England
Citazione:
P. Postma et al., "Startle response during smoking and 24 h after withdrawal predicts successful smoking cessation", PSYCHOPHAR, 156(2-3), 2001, pp. 360-367

Abstract

Rationale: The startle response is thought to reflect changes in attentional processes in humans. The startle response shows a number of forms of plasticity, of which prepulse inhibition (PPI) refers to the attenuation of the startle response to a strong sensory stimulus (pulse), when such a pulse is preceded by a stimulus of lower intensity (prepulse). Recent studies have shown that nicotine modulates startle and PPI of the startle reflex in humans and animals. The present study examined individual differences in cognitive benefits obtained from smoking as indexed by startle response and PPI. Objectives: We investigated, using a within-subjects design, the effects of cigarette smoking via a comparison of baseline and withdrawal measures of startle and PPI in 18 subjects wishing to quit cigarette smoking. The relapse of five of these subjects enabled a between-group comparison of these measures with the successful quitters. Methods: Startle and PPI were measured on three separate occasions: before quitting, 24 h after quitting and I month after quitting. Results: The presence of a high startle response amplitude while subjects were still engaged in their normal smoking patterns (baseline) and the occurrence of a significant drop of startle amplitude in withdrawal relative to baseline factors were found to be predictive of an individual's ability to quit smoking. Changes in PPI were found to reflect these changes in startle amplitude. Conclusions: The observed response patterns are discussed in terms of individual differences in commitment to quitting and self-dosing to manipulate attentional mechanisms as measured by the acoustic startle response. Furthermore, it is suggested that these specificresponse profiles may be predictive of the ability to quit smoking.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 14:46:49