Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Auditory information processing in rat genotypes with different dopaminergic properties
Autore:
de Bruin, NMWJ; van Luijtelaar, ELJM; Cools, AR; Ellenbroek, BA;
Indirizzi:
Univ Nijmegen, Dept Comparat & Physiol Psychol, NL-6500 HE Nijmegen, Netherlands Univ Nijmegen Nijmegen Netherlands NL-6500 HE 0 HE Nijmegen, Netherlands
Titolo Testata:
PSYCHOPHARMACOLOGY
fascicolo: 2-3, volume: 156, anno: 2001,
pagine: 352 - 359
Fonte:
ISI
Lingua:
ENG
Soggetto:
PREPULSE INHIBITION; ACOUSTIC STARTLE; NUCLEUS-ACCUMBENS; NEUROPHYSIOLOGICAL EVIDENCE; APOMORPHINE SUSCEPTIBILITY; SENSORY INHIBITION; EVOKED-POTENTIALS; LOW RESPONDERS; ANIMAL-MODELS; SCHIZOPHRENIA;
Keywords:
auditory evoked potentials (AEPs); dopamine (DA); mesolimbic system; nigrostriatal system; prepulse inhibition (PPI); rat genotype; schizophrenia; sensory gating;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
65
Recensione:
Indirizzi per estratti:
Indirizzo: de Bruin, NMWJ Univ Nijmegen, Dept Comparat & Physiol Psychol, POB 9104, NL-6500 HE Nijmegen, Netherlands Univ Nijmegen POB 9104 Nijmegen Netherlands NL-6500 HE nds
Citazione:
N.M.W.J. de Bruin et al., "Auditory information processing in rat genotypes with different dopaminergic properties", PSYCHOPHAR, 156(2-3), 2001, pp. 352-359

Abstract

Rationale: Auditory filtering disturbances, as measured in the sensory gating and prepulse inhibition (PPI) paradigms, have been linked to aberrant auditory information processing and sensory overload in schizophrenic patients. In both paradigms, the response to the second stimulus (S2) is attenuated by an inhibitory effect of the first stimulus (S1). Dopamine (DA) agonists have been found to reduce gating of auditory evoked potentials (AEPs) and PPI in healthy human subjects and in rats. These effects have been linkedto DA hyperactivity in the mesolimbic system. A non-invasive approach in studying the role of the DA system in PPI and AEP gating is to compare rat genotypes that are marked by distinct DA systems. Objectives: Several questions were asked in the present study. Are PPI and AEP gating disturbed in (a) rats that are marked by a relatively high DA reactivity of the mesolimbicsystem, namely apomorphine-susceptible (APO-SUS) and WAG/Rij rats or in (b) rats that are marked by a relatively high DA activity of the nigrostriatal system, namely apomorphine-unsusceptible (APO-UNSUS) and ACI rats? Moreover. is the particular DA balance (c) between the nigrostriatal and mesolimbic system related to deficits in PPI and AEP gating? Methods: For this purpose, the above-mentioned four rat genotypes (APO-SUS, APO-UNSUS, ACI and WAG/Rij) that vary in DA balance between both systems, were compared in the AEP gating paradigm. PPI was only measured in the ACI and WAG/Rij rats, since it has already been shown in a previous study that APO-SUS rats show diminished PPI as compared to rats of the APO-UNSUS genotype. Results: AEP gating of the vertex N50 was significantly reduced in WAG/Rij rats as compared to the remaining three rat genotypes (APO-SUS, APO-UNSUS and ACI). No PPI deficits were found in the ACI and WAG/Rij rats, although ACI rats had a significantly higher basal startle amplitude. Conclusions: The PPI deficit in APO-SUS and not in the other genotypes, suggests that especially a relatively high DA reactivity of the mesolimbic system, together with a relatively low activity of the nigrostriatal system, contributes to this deficit. In contrast, the N50 gating deficit in WAG/Rij rats and not in the other genotypes suggests that a relatively high DA activity of the nigrostriatal systemtogether with a relatively high DA reactivity of the mesolimbic system is necessary for the presence of a N50 gating deficit. On the basis of these results we have concluded that both auditory filtering processes are differently regulated by DA in the nigrostriatal and mesolimbic systems.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 00:42:39