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Titolo:
Environmental animal models for sensorimotor gating deficiencies in schizophrenia: a review
Autore:
Weiss, IC; Feldon, J;
Indirizzi:
ETH Zurich, Behav Neurobiol Lab, Zurich, Switzerland ETH Zurich Zurich Switzerland Behav Neurobiol Lab, Zurich, Switzerland Swiss Fed Inst Technol, Behav Neurobiol Lab, CH-8603 Schwerzenbach, Switzerland Swiss Fed Inst Technol Schwerzenbach Switzerland CH-8603 ch, Switzerland
Titolo Testata:
PSYCHOPHARMACOLOGY
fascicolo: 2-3, volume: 156, anno: 2001,
pagine: 305 - 326
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEDIAL PREFRONTAL CORTEX; ACOUSTIC STARTLE RESPONSE; INFORMATION-PROCESSING DEFICITS; EXCITOTOXIC HIPPOCAMPAL DAMAGE; PREPULSE INHIBITION DEFICITS; CONDITIONED PLACE PREFERENCE; FEAR-POTENTIATED STARTLE; REARING-INDUCED DEFICITS; PITUITARY-ADRENAL AXIS; ISOLATION-REARED RATS;
Keywords:
schizophrenia; prepulse inhibition; animal models; rat; early handling; maternal separation; social isolation;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
210
Recensione:
Indirizzi per estratti:
Indirizzo: Feldon, J ETH Zurich, Behav Neurobiol Lab, Zurich, Switzerland ETH ZurichZurich Switzerland robiol Lab, Zurich, Switzerland
Citazione:
I.C. Weiss e J. Feldon, "Environmental animal models for sensorimotor gating deficiencies in schizophrenia: a review", PSYCHOPHAR, 156(2-3), 2001, pp. 305-326

Abstract

Rationale: In schizophrenia research, the study of animal models has received considerable attention in the past 20 years. The value of animal modelsin preclinical research is widely recognised, largely because they can provide precious knowledge regarding the neurobiology of schizophrenia and canalso be used for developing antipsychotic drugs. Prepulse inhibition (PPI;reduction in startle reflex induced by a prestimulus) is impaired in schizophrenic patients, a finding that has been associated with a loss of sensorimotor gating abilities. In rats, the schizophrenic-like PPI deficit can beinduced by pharmacological or surgical manipulations targeting mainly the cortico-meso-limbic circuitry. Objectives: The literature was critically reviewed in an effort to determine the robustness and the relevance for schizophrenia of another category of animal models, based purely on manipulations of the social environment, that encompasses the neurodevelopmental hypothesis of schizophrenia. Specifically, we focused our attention on the long-term effects of such environmental models on sensorimotor gating processes as assessed in the PPI paradigm, with an attempt to evaluate their face, predictive and construct validity. Results: Our review of the literature leadsto the conclusion that social deprivation performed directly after weaning(similar to 21 days of age) is more likely to be a relevant model for PPI impairments in schizophrenia than pre-weaning manipulations. Conclusions: Although the robustness of such environmental models requires further study,these animal models offer the advantage of avoiding invasive manipulations, which allows for a variety of anatomical, electrophysiological, neuroendocrine or neurochemical investigations in the absence of confounding pharmacological or surgical effects.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/01/20 alle ore 20:57:44