Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Effects of acute versus chronic treatment with typical or atypical antipsychotics on d-amphetamine-induced sensorimotor gating deficits in rats
Autore:
Andersen, MP; Pouzet, B;
Indirizzi:
H Lundbeck AS, Dept Psychopharmacol, DK-2500 Valby, Denmark H Lundbeck ASValby Denmark DK-2500 chopharmacol, DK-2500 Valby, Denmark
Titolo Testata:
PSYCHOPHARMACOLOGY
fascicolo: 2-3, volume: 156, anno: 2001,
pagine: 291 - 304
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHENCYCLIDINE-INDUCED DISRUPTION; PREPULSE INHIBITION; STARTLE RESPONSE; ACOUSTIC STARTLE; ANIMAL-MODEL; SCHIZOPHRENIC-PATIENTS; TREATED RATS; APOMORPHINE; HALOPERIDOL; CLOZAPINE;
Keywords:
prepulse inhibition; haloperidol; olanzapine; sertindole; hyperactivity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Pouzet, B H Lundbeck AS, Dept Psychopharmacol, 7-9 Ottiliavej, DK-2500 Valby, Denmark H Lundbeck AS 7-9 Ottiliavej Valby Denmark DK-2500 lby, Denmark
Citazione:
M.P. Andersen e B. Pouzet, "Effects of acute versus chronic treatment with typical or atypical antipsychotics on d-amphetamine-induced sensorimotor gating deficits in rats", PSYCHOPHAR, 156(2-3), 2001, pp. 291-304

Abstract

Rationale: Dopamine (DA) receptor agonists disrupt the prepulse inhibition(PPI) in rats which is considered to model PPI deficits observed in schizophrenic patients. Many laboratories have demonstrated that both "typical" and "atypical" antipsychotics reverse the disruptive effect of DA agonists on PPI in rats. These results are based on acute treatment with antipsychotics, which is different from clinical observations since humans receive treatment for months and the effects of antipsychotics only emerge after weeks of treatment. Objectives: We aimed to investigate the effect of chronic treatment with "typical" and "atypical" antipsychotics on the PPI model in rats. Methods: We investigated the effect of acute versus sub-chronic (3 days)and chronic (21 days) treatment with haloperidol or two "atypical" antipsychotics (olanzapine; sertindole) on d-amphetamine-disrupted PPI in rats. Results: We observed that all three antipsychotics dose-dependently reversed the disruptive effect of d-amphetamine after acute or sub-chronic treatment, but that this reversal effect disappeared after chronic treatment. We confirmed this effect in the same model using oral administration instead of mini-pumps, and in an additional model predictive of antipsychotic action, i.e. d-amphetamine-induced hyperactivity in rats. Conclusions: The d-amphetamine-disrupted PPI model highlighted a modification in the effects of antipsychotics after chronic treatment when compared to their acute effects, butonly the acute treatment can be considered predictive of antipsychotic action in clinic.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 20:04:50